Ocular Assessments of a Series of Newborns Gestationally Exposed to Maternal COVID-19 Infection.

JAMA Ophthalmology
Olívia Pereira KiappeNilva Simeren Bueno de Moraes

Abstract

Congenital viral infections leading to ocular abnormalities are frequent and devastating. As ophthalmological manifestations of COVID-19 in newborns are still unknown, it is important to clarify if SARS-CoV-2 could be associated with ocular abnormalities. To determine whether exposure to SARS-CoV-2 is associated with outcomes in the eyes of newborns. This case series enrolled newborns from April to November 2020 from 3 different maternity hospitals in São Paulo, Brazil. The diagnosis of COVID-19 in mothers and newborns was based on real-time reverse transcriptase-polymerase chain reaction assays with material obtained from oronasopharyngeal swab sample; positive IGM serology was also considered as a diagnostic test for mothers. Newborns were excluded if they had any evidence of another congenital infection. All infants underwent external ocular examination and binocular indirect ophthalmoscopy. Serology test for COVID-19 and detection of SARS-CoV-2 from oronasopharyngeal specimen using a real-time reverse transcriptase-polymerase chain reaction assay on both mothers and newborns. Screening for ophthalmologic manifestation in newborns after maternal COVID-19 infection. A total of 165 newborns (age range at examination, 1 to 18 d...Continue Reading

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