Sep 18, 2010

Ocular biomarkers for early detection of Alzheimer's disease

Journal of Alzheimer's Disease : JAD
S FrostY Kanagasingam


Alzheimer's disease (AD) is the most common form of dementia and is clinically characterized by a progressive decline in memory, learning, and executive functions, and neuropathologically characterized by the presence of cerebral amyloid deposits. Despite a century of research, there is still no cure or conclusive premortem diagnosis for the disease. A number of symptom-modifying drugs for AD have been developed, but their efficacy is minimal and short-lived. AD cognitive symptoms arise only after significant, irreversible neural deterioration has occurred; hence there is an urgent need to detect AD early, before the onset of cognitive symptoms. An accurate, early diagnostic test for AD would enable current and future treatments to be more effective, as well as contribute to the development of new treatments. While most AD related pathology occurs in the brain, the disease has also been reported to affect the eye, which is more accessible for imaging than the brain. AD-related proteins exist in the normal human eye and may produce ocular pathology in AD. There is some homology between the retinal and cerebral vasculatures and the retina also contains nerve cells and fibers that form a sensory extension of the brain. The eye is ...Continue Reading

  • References
  • Citations20


  • We're still populating references for this paper, please check back later.

Mentioned in this Paper

Familial Alzheimer Disease (FAD)
Neurobehavioral Manifestations
Science of Morphology
Plaque, Amyloid
Retinal Diseases
Orbital Region
Alzheimer's Disease

Related Feeds

Alzheimer's Disease: Early Markers

Alzheimer's disease is a chronic neurodegenerative disease. This feed focuses on early markers, as well as environmental, pharmacological, and drug-response biomarkers associated with this disease.

Alzheimer's Disease: Animal models

Alzheimer's disease is a chronic neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Alzheimer's Disease: Abeta

Alzheimer's disease (AD) is a chronic neurodegenerative disease associated with accumulation of amyloid plaques, which are comprised of amyloid beta. Here is the latest research in this field.

Alzheimer's Disease: RNA Regulation

RNA regulation involves several mechanisms that are used by cells to decreases or increase the production of RNA. Issues with RNA regulation are associated with Alzheimer's Disease (AD). Here are the latest discoveries pertaining to RNA regulation and this disease.

Related Papers

Journal of Neurology, Neurosurgery, and Psychiatry
Mohammad Kamran IkramChristopher P L H Chen
Clinical Chemistry and Laboratory Medicine : CCLM
David Prvulovic, Harald Hampel
Current Topics in Medicinal Chemistry
Alexandre CoimbraEric D Hostetler
© 2020 Meta ULC. All rights reserved