Ocular biomarkers of Alzheimer's disease

Central Nervous System Agents in Medicinal Chemistry
George R HeatonMaria F Cordeiro

Abstract

Alzheimer's disease (AD) is a devastating neurodegenerative disease characterised clinically by a progressive decline in executive functions, memory and cognition. Classic neuropathological hallmarks of AD include intracellular hyper-phosphorylated tau protein which forms neurofibrillary tangles (NFT), and extracellular deposits of amyloid β (Aβ) protein, the primary constituent of senile plaques (SP). The gradual process of pathogenic amyloid accumulation is thought to occur 10-20 years prior to symptomatic manifestation. Advance detection of these deposits therefore offers a highly promising avenue for prodromal AD diagnosis. Currently, the most sophisticated method of 'probable AD' diagnosis is via neuroimaging or cerebral spinal fluid (CSF) biomarker analysis. Whilst these methods have reported a high degree of diagnostic specificity and accuracy, they fall significantly short in terms of practicality; they are often highly invasive, expensive or unsuitable for large-scale population screening. In recent years, ocular screening has received substantial attention from the scientific community due to its potential for non-invasive and inexpensive central nervous system (CNS) imaging. In this appraisal we build upon our previo...Continue Reading

Citations

Aug 22, 2015·Eye·S I BalendraM F Cordeiro
Aug 22, 2016·Acta Neuropathologica·Benjamin Michael DavisMaria Francesca Cordeiro
Dec 17, 2016·Drug Discovery Today. Technologies·Meena Subramanyam, Jaya Goyal
Apr 6, 2017·Journal of Neuropathology and Experimental Neurology·Erik A WilliamsAnat Stemmer-Rachamimov
Dec 9, 2017·Acta Ophthalmologica·Deepti Mahajan, Marcela Votruba
May 22, 2018·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Cláudia Y SantosPeter J Snyder
Apr 21, 2018·International Journal of Molecular Sciences·Timothy E YapMaria Francesca Cordeiro
Aug 12, 2019·Ophthalmic Research·Timothy E YapM Francesca Cordeiro

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