PMID: 11340511May 8, 2001Paper

Ocular complications after treatment with intravenous cidofovir for cytomegalovirus retinitis

Archivos de la Sociedad Española de Oftalmología
J M Martínez de la CasaJ García Sánchez

Abstract

To describe the ocular changes observed in six patients treated with intravenous cidofovir for cytomegalovirus retinitis. We have studied six patients (12 eyes) treated with intravenous cidofovir. A complete ophthalmologic examination was performed before and after each dose during the follow-up period, paying special attention to intraocular pressure changes. Three cases of non-granulomatous anterior uveitis with good response to conventional treatment were detected. The intraocular pressure decreased after the administration of the two first doses of the drug (p<0.01), and was followed by stabilization of the intraocular pressure with the next doses. In two of the eyes (16.7%), the decrease in the intraocular pressure was more than 50% in comparison to the measurements at the onset of treatment. In three eyes (18.7%), we detected acute anterior uveitis, which responded well to conventional treatment. The intravenous administration of cidofovir for the treatment of cytomegalovirus retinitis is associated with important ocular changes that must be carefully observed in the follow-up of these patients.

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