Ocular concentrations of mitomycin C using different delivery devices

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
H MietzG K Krieglstein

Abstract

Hypotony and its sequelae are a frequent complication of trabeculectomies performed with mitomycin C (MMC), possibly related to intraocular toxicity of the substance. In an animal model with rabbits, we used different devices for the application of MMC and measured extra- and intraocular concentrations by HPLC. In addition, the concentrations of MMC remaining in the devices were determined. The devices were (1) a regular surgical sponge, (2) a scleral shield, (3) a presoaked soft contact lens, (4) a soft contact lens with MMC application, and (5) subconjunctival injection. Ocular concentrations of MMC were similar within the first 4 groups and were highest in the last. The measurements suggest that MMC penetrates intraocularly regardless of the device used. The variability of remaining MMC concentrations in the devices was lowest in the soft contact lenses suggesting an improved delivery system compared to the usually used surgical sponges.

Citations

Sep 21, 2004·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sami Al-Shahwan, Deepak P Edward
Dec 19, 2012·Middle East African Journal of Ophthalmology·Ved P Gupta, Pragati Gupta
Jan 11, 2008·NMR in Biomedicine·S Kevin LiEun-Kee Jeong
May 19, 2019·Pharmaceutics·Ana Castro-BaladoAnxo Fernández-Ferreiro
Mar 17, 2020·Indian Journal of Ophthalmology·Devendra MaheshwariMohideen Abdul Kadar
Oct 28, 1999·Current Opinion in Ophthalmology·E K Donohue, G A Cioffi
Jan 6, 2004·Current Eye Research·C ZimmermanT Shaarawy

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