Ocular delivery systems for topical application of anti-infective agents

Drug Development and Industrial Pharmacy
Linda DuxfieldRaida Al-Kassas

Abstract

For the treatment of anterior eye segment infections using anti-infective agents, topical ocular application is the most convenient route of administration. However, topical delivery of anti-infective agents is associated with a number of problems and challenges owing to the unique structure of the eye and the physicochemical properties of these compounds. Topical ocular drug delivery systems can be classified into two forms: conventional and non-conventional. The efficacy of conventional ocular formulations is limited by poor corneal retention and permeation resulting in low ocular bioavailability. Recently, attention has been focused on improving topical ocular delivery of anti-infective agents using advanced drug delivery systems. This review will focus on the challenges of efficient topical ocular delivery of anti-infective agents and will discuss the various types of delivery systems used to improve the treatment anterior segment infections.

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Citations

May 4, 2016·International Journal of Pharmaceutics·Chutimon MuankaewThorsteinn Loftsson
Dec 31, 2017·Drug Delivery and Translational Research·Shubhmita BhatnagarVenkata Vamsi Krishna Venuganti
Apr 2, 2019·Pharmaceutical Development and Technology·Ahmed Abd El-BaryIbrahim Al Sharabi
Nov 30, 2018·Recent Patents on Anti-infective Drug Discovery·Javed AhmadKeerti Jain
Jul 31, 2020·Pharmaceutical Development and Technology·Abdullah AlyoussefAnant Paradkar
Aug 18, 2017·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Nicole CarntFiona Stapleton
Mar 7, 2020·Frontiers in Bioengineering and Biotechnology·Jeongmin HwangKristi L Kiick
Nov 28, 2021·Pharmaceuticals·Bharti GuptaAbdelwahab Omri

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