Ocular Demodex: a systematic review of the clinical literature.

Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)
Alexis Ceecee ZhangLaura E Downie

Abstract

There is increasing clinical and research interest in the potential contribution of Demodex to ocular surface disease. The aim of this systematic review was to summarise and synthesise current clinical evidence relating to the aetiology, diagnosis and treatment of ocular Demodex. A comprehensive literature search was performed in OVID Medline, OVID Embase, and clinical trial registries, for studies published between 1990 and August 2019, examining Demodex on the ocular surface. The review included primary clinical research studies and systematic reviews of primary clinical research studies, where Demodex was considered in the context of the ocular surface and/or adnexa. Studies were categorised using the National Health and Medical Research Council evidence hierarchy. Risk of bias assessment was performed using validated tools for studies categorised as providing Level I or II evidence. A total of 87 studies were eligible for inclusion, including two systematic reviews. Most studies (60%) were observational, describing the prevalence of ocular Demodex in different clinical populations. There was a high degree of variability in the epidemiological data derived from cross-sectional aetiology studies. There was mostly consistent e...Continue Reading

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Citations

Oct 11, 2020·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Emma C SandfordJennifer P Craig
Apr 2, 2021·Ocular Immunology and Inflammation·Ayse Yildiz-TasAfsun Sahin
May 9, 2021·The Ocular Surface·James S WolffsohnUNKNOWN TFOS ambassadors
Aug 2, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Roberto González SalinasHugo Quiroz-Mercado

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