Ocular dominance plasticity disrupts binocular inhibition-excitation matching in visual cortex

Current Biology : CB
M Hadi SaiepourChristiaan N Levelt

Abstract

To ensure that neuronal networks function in a stable fashion, neurons receive balanced inhibitory and excitatory inputs. In various brain regions, this balance has been found to change temporarily during plasticity. Whether changes in inhibition have an instructive or permissive role in plasticity remains unclear. Several studies have addressed this question using ocular dominance plasticity in the visual cortex as a model, but so far, it remains controversial whether changes in inhibition drive this form of plasticity by directly affecting eye-specific responses or through increasing the plasticity potential of excitatory connections. We tested how three major classes of interneurons affect eye-specific responses in normally reared or monocularly deprived mice by optogenetically suppressing their activity. We find that in contrast to somatostatin-expressing or vasoactive intestinal polypeptide-expressing interneurons, parvalbumin (PV)-expressing interneurons strongly inhibit visual responses. In individual neurons of normal mice, inhibition and excitation driven by either eye are balanced, and suppressing PV interneurons does not alter ocular preference. Monocular deprivation disrupts the binocular balance of inhibition and e...Continue Reading

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Citations

Sep 18, 2015·Frontiers in Cellular Neuroscience·Paola TogniniTommaso Pizzorusso
May 20, 2016·Cellular and Molecular Life Sciences : CMLS·Daniëlle van Versendaal, Christiaan N Levelt
Jan 18, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Irina ErchovaFrank Sengpiel
Dec 1, 2017·Nature Neuroscience·Jean-Pierre SommeijerChristiaan N Levelt
Jun 16, 2018·Visual Neuroscience·Takao K Hensch, Elizabeth M Quinlan
Aug 19, 2018·Scientific Reports·Daniela CamilloJ Alexander Heimel
Jul 18, 2021·Journal of Biochemical and Molecular Toxicology·Limin XuLijuan Lang

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