Ocular Findings in Alemtuzumab (Campath-1H)-induced Thyroid Eye Disease

Ophthalmic Plastic and Reconstructive Surgery
Tanya TrinhTimothy J Sullivan

Abstract

Alemtuzumab (Campath-1H) is a humanized anti-CD52 monoclonal antibody used in the treatment of multiple sclerosis (MS). Studies demonstrate significant reduction in relapse risk and the risk of accumulating sustained disability. Adverse events include infusion-associated reactions, infections, and secondary autoimmunity. Systemic thyroid disease is the most common secondary autoimmune event and affects up to approximately 30% of treated patients. This is the first description of the ocular findings and management in a case of thyroid eye disease (Graves' Ophthalmopathy [GO]) following alemtuzumab therapy. The ocular disease was managed conservatively while the systemic Graves' was managed with thyroidectomy.

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Citations

Jun 24, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Luminita N CimaSimona Fica
Jun 10, 2017·Current Opinion in Ophthalmology·Richard C Allen
Jul 2, 2019·Ophthalmic Plastic and Reconstructive Surgery·Alan A McNab
Oct 21, 2017·Ophthalmic Plastic and Reconstructive Surgery·Geraldine R Slean, Rona Z Silkiss
Aug 10, 2020·Neurology. Neuroimmunology and Neuroinflammation·Ethan MeltzerTeresa C Frohman
Feb 10, 2017·Drugs·Gregory HeathRichard Peter Gale
Jan 8, 2021·Multiple Sclerosis and Related Disorders·Joana Costa Novo, Helena Felgueiras

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