Ocular hypotension induced by intravitreally injected C-type natriuretic peptide

Experimental Eye Research
Y TakashimaN Yoshimura

Abstract

The purpose of the study is to determine if intravitreal injection of c-type natriuretic peptide (CNP) affects intraocular pressure (IOP), aqueous humor dynamics and guanosine 3',5'-cyclic monophosphate (cGMP) concentration in the aqueous humor of the rabbit eye. Also we investigated whether CNP-like immunoreactivities (CNP-LI) were present in porcine aqueous humor and whether CNP-LI were detected in rabbit and porcine ciliary body. The IOP was measured after intravitreal injection of 2 pmol approximately 20 nmol CNP into rabbit eyes. Aqueous humor dynamics (aqueous humor flow, outflow facility, and uveoscleral outflow) and cGMP concentration in the aqueous humor were determined at approximately 6 hr after CNP injection. The CNP concentration in aqueous was measured by radioimmunoassay in porcine eye, and CNP-LI were detected with a monoclonal antibody in porcine and rabbit eyes. Intravitreally injected CNP caused IOP reduction in a dose-dependent manner (P<0.0001) and the maximum effect was observed at 4 approximately 6 hr. CNP increased total outflow facility by approximately 35%, but did not affect aqueous humor flow or uveoscleral outflow. The cGMP concentration in the aqueous of CNP-treated eyes was about 4- to 14-fold hig...Continue Reading

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Citations

Oct 30, 2003·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Lichun ZhongTeh-Ching Chu
May 3, 2015·Experimental Eye Research·J Cameron Millar, Iok-Hou Pang
Jun 7, 2014·Frontiers in Molecular Neuroscience·Emmanuel S BuysBruce R Ksander
May 14, 2004·American Journal of Physiology. Cell Physiology·Pawel FidzinskiMiguel Coca-Prados
Jan 27, 2004·The Journal of Pharmacology and Experimental Therapeutics·David E PotterMarlina Manhiani
Dec 9, 2017·Current Medical Research and Opinion·Janusz SkrzypeckiMarcin Ufnal

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