Ocular hypotensive effect of systemic beta-blockers in patients with primary glaucoma and arterial hypertension

Vestnik oftalmologii
A L OnishchenkoN M Zhilina

Abstract

to evaluate the ocular hypotensive efficacy of systemic beta-blockers in primary glaucoma patients suffering from arterial hypertension (AH). The study included 29 patients with POAG (58 eyes) aged from 47 to 83 years. Patients with stage I-III POAG received instillations of prostaglandin analogs and carbonic anhydrase inhibitors. All POAG patients also suffered from arterial hypertension and were prescribed selective beta-blockers (metoprolol, bisoprolol, or nebivalol) as monotherapy or as part of combination therapy (if the target arterial pressure had not been achieved under the initial treatment). After the start of oral beta-blockers therapy, the patients were re-examined at 2 and 4 weeks, 3 months, 6 months, and 1 year. A clinically significant reduction of IOP in the most seriously affected eye - by 3.3 mmHg (p<0.05), or 14% - occurred four weeks after the start of selective beta-blockers. Over three months of combination therapy, IOP in the 'worst' eye decreased by 4.4 mmHg (18.5%). At 1 year, IOP in the 'worst' eye was 6.2 mmHg (26%) lower than at baseline (p<0.05). Aged and senile patients with primary glaucoma usually suffer from polypathy (on average, they have 6.3±0.6 concurrent somatic diseases). To reduce the ris...Continue Reading

References

Apr 1, 1967·The British Journal of Ophthalmology·C I PhillipsD J Rowlands
Mar 18, 1999·The American Journal of Cardiology·R van der DoesA Lahiri
Feb 27, 2004·Investigative Ophthalmology & Visual Science·Gabriele Fuchsjäger-MayrlLeopold Schmetterer
Feb 26, 2009·Current Opinion in Ophthalmology·M Cristina Leske
Oct 23, 2015·Vestnik oftalmologii·A L OnishchenkoM V Dimaksyan

❮ Previous
Next ❯

Citations

Jun 7, 2020·Vestnik oftalmologii·N V Eliseeva, M I Churnosov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.