Ocular hypotensive efficacy of travoprost in patients unsuccessfully treated with latanoprost

Current Medical Research and Opinion
Martin KabackSTART Study Group

Abstract

To evaluate the efficacy of travoprost 0.004% monotherapy in patients unsuccessfully treated with latanoprost monotherapy. Open-label, noncomparative study conducted at US academic and private practice clinics in adult patients with ocular hypertension or primary open-angle glaucoma who required a change in therapy (due to either inadequate efficacy or safety issues) as judged by the investigator. Intraocular pressure (IOP) was measured at entry and 30 days later. Mean change in intraocular pressure (mm Hg). Reported here are 488 per-protocol patients from 330 centers who were using latanoprost monotherapy prior to study entry, and who received travoprost monotherapy during the study. Patients had a mean age of 69 years, were approximately two-thirds Caucasian, 60% female, predominantly brown or blue eyes, and 91% were diagnosed as having primary open-angle glaucoma. The mean days in treatment were 31.9 +/- 6.4. Mean IOP at study entry was 21.2 mm Hg. Following travoprost monotherapy, this was reduced by a mean of 3.2 mm Hg to 18 mm Hg (p < 0.0001, paired t-test). There were 21 adverse events reported in the intent-to-treat (ITT) population for an incidence of 3.5%. There were some limitations to the current study including: no...Continue Reading

References

Jan 1, 1988·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·G D NovackA L Batoosingh
Sep 27, 2001·Advances in Therapy·S GandolfiUNKNOWN Bimatoprost Study Group 3
Oct 9, 2001·American Journal of Ophthalmology·P A NetlandUNKNOWN Travoprost Study Group
Jan 5, 2002·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·M R HellbergP W Zinke
Oct 9, 2002·Archives of Ophthalmology·Anders HeijlUNKNOWN Early Manifest Glaucoma Trial Group
Oct 9, 2002·Archives of Ophthalmology·Eve J HigginbothamUNKNOWN Bimatoprost Study Groups 1 and 2
Oct 9, 2002·Archives of Ophthalmology·Paul R Lichter
Oct 30, 2003·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Thom J ZimmermanUNKNOWN Latanoprost Axis Study Group
Oct 30, 2003·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Naj A SharifAta A Abdel-Latif

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Citations

Jun 7, 2012·Japanese Journal of Ophthalmology·Ichiro KawaguchiKazuhisa Sugiyama
Jan 2, 2007·Cornea·Paul J HarasymowyczUNKNOWN Travoprost Central Corneal Thickness Study Group
Dec 22, 2006·Expert Opinion on Drug Safety·Gábor Holló
Aug 31, 2006·Cardiovascular Drug Reviews·Naruhiro IshidaHideaki Hara

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