Ocular Involvement Following an Epidemic of Toxoplasma gondii Infection in Santa Isabel do Ivaí, Brazil

American Journal of Ophthalmology
Cláudio SilveiraR Belfort

Abstract

To investigate ocular involvement (prevalence, incidence, lesion characteristics) following postnatally acquired infection with an "atypical" genotype of Toxoplasma gondii during a well-characterized 2001 outbreak in Santa Isabel do Ivaí, Brazil, attributed to a contaminated municipal reservoir. Prospective longitudinal cohort study. We performed ophthalmic examinations on 290 of 454 individuals with serologic evidence of T gondii infection during the epidemic (positive IgM antibody tests). Prevalence of ophthalmic findings (intraocular inflammatory reactions [including transient, isolated retinal whitening without clinically apparent retinal necrosis] and necrotizing retinochoroiditis) at initial examination (baseline) and incidence of new findings during 10.5 months of follow-up were calculated. Cumulative risks of ophthalmic events were determined (Kaplan-Meier technique). Ocular involvement was present in 33 of 288 IgM+ individuals (11.5%) at baseline, including 17 with focal retinal whitening only and 13 with necrotizing retinochoroiditis. Incidence of new ocular involvement was estimated to be 1.73 events per 100 person-months (PM); cumulative risk at 10.5 months was 30.1%. Incident necrotizing retinochoroiditis was more ...Continue Reading

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Citations

Sep 26, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Despina Contopoulos-IoannidisRima McLeod
Mar 7, 2015·American Journal of Ophthalmology·Tiago E F ArantesRubens Belfort
Jul 16, 2016·Vector Borne and Zoonotic Diseases·Ariella A MarchioroAna L Falavigna-Guilherme
Sep 9, 2016·International Journal of Environmental Health Research·Carla Zangari de SouzaAna Lúcia Falavigna-Guilherme
Jun 24, 2017·The Pediatric Infectious Disease Journal·Ana Paula SandersAna Lucia Falavigna-Guilherme
Sep 14, 2018·Clinical Microbiology Reviews·Ildiko Rita DunayJose G Montoya
Apr 13, 2018·Open Forum Infectious Diseases·Andrés F Henao-MartínezJose G Montoya
Dec 4, 2018·EFSA Journal·UNKNOWN EFSA Panel on Biological Hazards (BIOHAZ)Lucy Robertson
Sep 10, 2020·The American Journal of Tropical Medicine and Hygiene·Marcelo RudzinskiJosé Raúl Oubiña
Nov 22, 2020·Emerging Infectious Diseases·Camilo Brandão-de-ResendeDaniel Vitor Vasconcelos-Santos
Jul 28, 2020·Progress in Retinal and Eye Research·Justine R SmithJoão M Furtado

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