Ocular Involvement Following Postnatally Acquired Toxoplasma gondii Infection in Southern Brazil: A 28-Year Experience

American Journal of Ophthalmology
Tiago E F ArantesRubens Belfort

Abstract

To determine the incidence of, and risk factors for, ocular involvement among people known to have postnatally acquired Toxoplasma gondii infection in a region of southern Brazil where there is a high prevalence of endemic disease. Retrospective longitudinal cohort study. Records of 302 patients with serologic evidence of recent T gondii infection (a positive anti-T gondii IgM antibody test) from Erechim, Rio Grande do Sul state, Brazil (1974-2002) were analyzed. The incidence of ocular involvement was calculated in terms of person-years (PY) of follow-up. Risk factors for ocular involvement were analyzed using log-rank and Fisher exact tests. At initial ocular examination (baseline), 30 patients (9.9%) had intraocular inflammation only (anterior chamber cells and flare, vitreous inflammatory reactions, retinal whitening), without clinically apparent necrotizing retinochoroiditis. At baseline, men were more likely to have ocular involvement (P = .043) and antiparasitic treatment was associated with less ocular involvement (P = .015). Follow-up examinations were performed on 255 patients (median follow-up, 13.7 months [range 0.4-261.9 months]). Among those without ocular involvement at baseline, the incidence of necrotizing reti...Continue Reading

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Citations

Mar 7, 2015·American Journal of Ophthalmology·Claudio SilveiraRubens Belfort
May 10, 2015·American Journal of Ophthalmology·Michael E GriggRobert B Nussenblatt
Dec 15, 2015·PloS One·Fausto AlmeidaMaria Cristina Roque-Barreira
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Mar 12, 2020·Ocular Immunology and Inflammation·Camilo Brandão-de-ResendeDaniel V Vasconcelos-Santos
Dec 19, 2019·Frontiers in Cellular and Infection Microbiology·David Arranz-SolísJeroen P J Saeij
May 11, 2018·The Korean Journal of Parasitology·Bahman Rahimi-EsboeiMirataollah Salabati
Sep 14, 2018·Clinical Microbiology Reviews·Ildiko Rita DunayJose G Montoya
Jan 27, 2019·BMC Infectious Diseases·Alejandra de-la-TorreJorge Enrique Gómez-Marín
Nov 22, 2020·Emerging Infectious Diseases·Camilo Brandão-de-ResendeDaniel Vitor Vasconcelos-Santos
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Jul 10, 2021·Ocular Immunology and Inflammation·Dimitrios KalogeropoulosAlejandra de-la-Torre
Aug 20, 2019·Microbiological Research·Yang ZhangYun Zhang

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