PMID: 9547859Apr 21, 1998Paper

Ocular irritation: microscopic changes occurring over time in the rat with surfactants of known irritancy

Toxicologic Pathology
J K MaurerG J Carr

Abstract

The pathology of surfactant-induced ocular irritation, especially in the context of accidental human exposures and animal tests used to assess a surfactant's potential ocular irritation, is not well understood. The purpose of this study was to characterize the microscopic changes in rats at 3 hr and on days 1, 2, 3, 4, 7, 14, and 35 following treatment with anionic, cationic, and nonionic surfactants of differing irritancy. The right eye of each rat was treated by placing 10 microliters of a surfactant directly on the cornea. Untreated left eyes served as the controls. At each time point, eyes and eyelids were macroscopically examined and collected for microscopic examination. Macroscopically, the differing levels of irritation were characterized by differences in incidence and magnitude of scores, reflecting involvement of the cornea, conjunctiva, and iris, as well as by the incidence of neovascularization and time to recovery. Microscopically, differences in the area and depth of injury paralleled the differences seen grossly and the relative irritancy of the various surfactants. All surfactants affected the corneal and conjunctival epithelium. All surfactants, except the slightly irritating anionic surfactant, caused corneal...Continue Reading

References

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Citations

Apr 5, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J V JesterJ K Maurer
Jul 6, 2014·BioMed Research International·Ranjan Ku SahooKetousetuo Kuotsu
Dec 22, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Douglas A DonahueDaniel R Cerven
Jul 21, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Rachael DayJ Allister Vale
Oct 18, 2016·Journal of Pharmaceutical and Biomedical Analysis·Petra FürediImre Klebovich
Dec 10, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Rachael DayJ Allister Vale
Nov 14, 2017·Drug Delivery·Maryam KhatoonAhmad Nawaz Khan
Dec 24, 2005·Cornea·Kai-Ling PengJui-Yang Lai
Jul 16, 2021·Therapeutic Advances in Ophthalmology·Zeynep Katipoğlu, Nazmi Zengin

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