Ocular lesions in leptin receptor-deficient medaka (Oryzias latipes )

Journal of Toxicologic Pathology
Shin-Ichi ChisadaAkihiko Sugiyama

Abstract

Ocular lesions in leptin receptor-deficient medaka were examined histopathologically at 10, 28, and 37 weeks post hatching. Leptin receptor-deficient medaka at 28 and 37 weeks old showed hyperglycemia and hypoinsulinemia. Histopathologically, vacuolation, swelling, fragmentation, and liquefaction of the lens fibers and dilatation of the retinal central veins, retinal capillaries, iridal veins and capillaries, and choroidal veins were observed in leptin receptor-deficient medaka at 28 and 37 weeks old. Thinning of the total retina, pigment epithelial layer, layer of rods and cones, outer granular layer, outer plexiform layer, inner granular layer, and inner plexiform layer was observed in leptin receptor-deficient medaka at 28 and 37 weeks compared with in control medaka. These histopathological characteristics in leptin receptor-deficient medaka are similar to characteristics in ocular lesions of rodent models for type II diabetes mellitus, making leptin receptor-deficient medaka a useful model of diabetic cataract and retinopathy.

References

Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·O A MacDougaldM D Lane
Jul 28, 1995·Science·M A PelleymounterF Collins
Apr 1, 1997·The British Journal of Ophthalmology·J K KristinssonE Stefánsson
Jul 27, 2001·International Journal of Experimental Diabetes Research·M ShinoharaY Kanazawa
Apr 28, 2004·Diabetes·William A BanksJohn E Morley
Sep 30, 2004·Acta Ophthalmologica Scandinavica·Nynne Christoffersen, Michael Larsen
Jul 1, 2005·Physiological Reviews·Olaf Strauss
Mar 31, 2006·Diabetes/metabolism Research and Reviews·Akihiro KakehashiYasunori Kanazawa
Dec 13, 2006·Genome Biology·Yoshihito TaniguchiEdwin Cuppen
Jun 9, 2009·Progress in Retinal and Eye Research·Debarshi MustafiKrzysztof Palczewski
Jun 16, 2009·General and Comparative Endocrinology·Tadahide Kurokawa, Koji Murashita
Sep 16, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ansgar S OlsenRobert V Intine
Nov 15, 2011·Diabetes Research and Clinical Practice·David R WhitingJonathan Shaw
Oct 12, 2012·Experimental Diabetes Research·Junghyun KimJin Sook Kim
Feb 15, 2013·American Journal of Nephrology·Keiji KonoShinichi Nishi
May 4, 2013·Investigative Ophthalmology & Visual Science·Ji Ho YangSeung Young Yu
Nov 29, 2013·Journal of Diabetes Research·Angela Ka Wai Lai, Amy C Y Lo
May 9, 2014·Current Diabetes Reviews·Bingxuan WangJohn J Pippin
Dec 9, 2014·The International Journal of Biochemistry & Cell Biology·Dong-Il KimSoo-Hyun Park
Jan 24, 2015·Oxidative Medicine and Cellular Longevity·Paphaphat ThiraphatthanavongBhalang Suriharn
Feb 17, 2015·World Journal of Diabetes·Nihat SayinGökhan Pekel
Feb 18, 2016·Biochimica Et Biophysica Acta·VictoriaBelén Ayala-PeñaOlga Lorena German
Apr 17, 2017·Vision Research·Judith LechnerAlan W Stitt

❮ Previous
Next ❯

Citations

Nov 14, 2019·Journal of Toxicologic Pathology·Shinichi Chisada, Akihiko Sugiyama

❮ Previous
Next ❯

Methods Mentioned

BETA
OLETF

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved