Ocular Manifestations and Visual Outcome in Children With Congenital Zika Syndrome

Topics in Magnetic Resonance Imaging : TMRI
Camila V VenturaLiana O Ventura

Abstract

The recent Zika virus (ZIKV) outbreak and the link to birth defects in newborns exposed in utero, caught international attention. Due to its rapid spread throughout the Americas, authorities declared ZIKV a Public Health Emergency of International Concern that lasted from February to November 2016."Congenital Zika Syndrome" (CZS) is a new entity that reflects a broad spectrum of symptoms and signs observed in newborns infected by the ZIKV in utero. A recent review concluded that CZS differs from other congenital infections for its five distinct features: "(1) severe microcephaly with partially collapsed skull; (2) thin cerebral cortices with subcortical calcifications; (3) macular scarring and focal pigmentary retinal mottling; (4) congenital contractures; and (5) marked early hypertonia and symptoms of extrapyramidal involvement."Diagnosing and managing CZS has become a challenge for health professionals including ophthalmologists. The ocular manifestations of CZS are unique and have important consequences on vision. This article reviews the ocular manifestations of the CZS, addresses the visual outcomes of affected infants, and elucidates the early intervention protocols for visual improvement.

References

Aug 1, 1991·Developmental Medicine and Child Neurology·E E Birch, M C Bane
May 17, 2002·Seminars in Neonatology : SN·G N Dutton, L K Jacobson
Jul 11, 2007·Journal of Child Neurology·Elisa FazziPaolo Emilio Bianchi
Oct 31, 2012·Pediatrics·Joseph M MillerUNKNOWN American Association of Certified Orthoptists
Jan 18, 2016·Lancet·Camila V VenturaRubens Belfort
Feb 4, 2016·Arquivos brasileiros de oftalmologia·Camila V VenturaLiana O Ventura
Feb 4, 2016·Arquivos brasileiros de oftalmologia·Bruno M Fontes
Mar 10, 2016·Journal of Korean Medical Science·Jacob Lee
Mar 31, 2016·The New England Journal of Medicine·Lyle R PetersenMargaret A Honein
May 30, 2016·Ophthalmology·Homero Augusto de MirandaDarius M Moshfeghi
Jun 10, 2016·Nature·Fernanda R CugolaPatricia C B Beltrão-Braga
Jun 12, 2016·Lancet·Camila V VenturaRubens Belfort
Jun 23, 2016·The New England Journal of Medicine·João M FurtadoBenedito A da Fonseca
Jul 20, 2016·The New England Journal of Medicine·Indira U Mysorekar, Michael S Diamond
Oct 25, 2016·Ophthalmology·D Wilkin ParkeRobert A Mittra
Aug 12, 2016·BMJ : British Medical Journal·Vanessa van der LindenRegina Coeli Ramos
Sep 2, 2016·MMWR. Morbidity and Mortality Weekly Report·Mariana C LealSilvio S Caldas Neto
Nov 5, 2016·JAMA Pediatrics·Cynthia A MooreSonja A Rasmussen
Dec 5, 2016·Ophthalmology·Bruno de Paula FreitasRubens Belfort
Jan 27, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anthony N van den PolJohn N Davis
Mar 10, 2017·JAMA Ophthalmology·Christopher R HenryJanet L Davis
Apr 19, 2017·JAMA Ophthalmology·Juan B YepezUNKNOWN Johns Hopkins Zika Center
Apr 30, 2017·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Liana O VenturaMarilyn T Miller
Jun 28, 2017·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Islane VerçosaMarcia B Tartarella
Jul 6, 2017·Ophthalmology·Bruno de Paula FreitasRubens Belfort
Jul 18, 2017·JAMA Pediatrics·Andrea A ZinMaria Elisabeth Lopes Moreira
Oct 5, 2017·JAMA Ophthalmology·Maria P FernandezSander R Dubovy
Oct 27, 2017·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Liana O VenturaLea Hyvärinen
Apr 15, 2018·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Liana O VenturaLinda Lawrence

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Citations

Aug 3, 2020·Current Opinion in Ophthalmology·J Clay BavingerSteven Yeh
Aug 9, 2020·International Journal of Retina and Vitreous·Sofía M MunsAudina M Berrocal
Jan 31, 2021·Eye·Ashwin VenkateshParwez Hossain
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Viviane Souza de CamposDaniel Adesse
Jun 5, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Ana Márcia Menezes de OliveiraPaulo Ricardo Saquete Martins-Filho

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