PMID: 9174543Apr 1, 1997Paper

Ocular manifestations in adult T-cell leukemia/lymphoma

Annals of Hematology
K ShibataM Miyahara

Abstract

Ocular manifestations of adult T-cell leukemia/lymphoma (ATL) are rare events. However, several ocular lesions which resulted from human T-cell leukemia virus type I (HTLV-I) infection have been reported, including direct infiltration of ATL cells, cytomegalovirus retinitis, and HTLV-I-associated uveitis (HAU). The aim of this study was to characterize ocular involvement in ATL and to correlate these lesions with HTLV-I proviral DNA integration. Three patients with acute-type ATL and ocular lesions were evaluated hematologically and ophthalmologically. Analysis of HTLV-I proviral DNA was carried out with a standard Southern blot technique using DNA from abnormal lymphocytes in peripheral blood. Two patients developed intraocular lesions located within intermediate and/or posterior segments which were caused by infiltration of ATL cells. Ocular lesions in one patient, which were localized to the anterior-intermediate segment, closely resembled those of HAU. Analysis of HTLV-I proviral DNA revealed multiple integrations in all three patients. The present study indicated heterogeneity in ocular manifestations of ATL. Multiple HTLV-I proviral DNA integrations may be associated with intraocular involvement in this disease.

Citations

Apr 24, 2013·Japanese Journal of Ophthalmology·Satoru KaseSusumu Ishida
Mar 10, 2001·American Journal of Ophthalmology·R R BuggageC C Chan
Apr 1, 2008·Middle East African Journal of Ophthalmology·E E Egbagbe, A E Omoti
Oct 22, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Pawan Kumar SinghManoranjan Mahapatra
Dec 5, 2009·Acta Ophthalmologica·Xiaoguang CaoChi-Chao Chan
May 27, 2004·Leukemia & Lymphoma·Styliani I KokorisGerassimos A Pangalis
Jan 1, 1998·Hematology·F Ravandi-KashaniF J Giles
Dec 28, 2017·Journal of Clinical and Experimental Hematopathology : JCEH·Joji ShimonoTakanori Teshima
Jul 4, 2018·The American Journal of Tropical Medicine and Hygiene·Selim FarèsHarold Merle
Feb 8, 2014·Korean Journal of Ophthalmology : KJO·Choul Yong ParkJong-Hyun Oh
Feb 8, 2000·Current Opinion in Ophthalmology·E Uchio, S Ohno
Mar 24, 2016·Ocular Immunology and Inflammation·Florence ChaputLaure E Caspers
Mar 29, 2020·Frontiers in Microbiology·Koju Kamoi

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