Ocular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies

Clinical Ophthalmology
Ammapati Paul Pandian Vignesh, Renuka Srinivasan

Abstract

To study the ocular manifestations of rheumatoid arthritis and to correlate the role of anti-cyclic citrullinated peptide antibody (anti-CCP antibody) with the ocular manifestations. Three-hundred and ninety-two eyes of the 196 rheumatoid arthritis patients who attended the ophthalmology outpatient department underwent a detailed ocular examination using slit lamp biomicroscopy and ophthalmoscopy. The tear function of all the patients was assessed using Schirmer's test, tear film break-up time and ocular surface staining. The anti-CCP antibody titers for all the rheumatoid arthritis patients were estimated using enzyme-linked immunosorbent assay tests. Seventy-seven patients (135 eyes, 39%) out of the 196 patients studied had ocular manifestations typical of rheumatoid arthritis. Dry eye was the most common manifestation (28%, 54 patients). Of the patients, 78% was females (60 patients). The mean duration of rheumatoid arthritis in patients with ocular manifestations was 5.4±2.7 years and without ocular manifestations was 2.1±1.6years. Three percent of the patients had episcleritis (six patients). Scleritis was present in 2% of the patients (four patients). Peripheral ulcerative keratitis and sclerosing keratitis was present in...Continue Reading

Citations

Apr 27, 2016·Clinical Rheumatology·Fabrício Silva LoboMárcia Midori Shinzato
Aug 25, 2020·Journal of Ophthalmology·Weifang MaCheng Li
Jun 3, 2021·Journal of Clinical Medicine·Veronique PromelleJulie Gueudry
Jul 9, 2021·Clinical Ophthalmology·Pilar Uribe-ReinaAlejandra de-la-Torre

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
confocal microscopy

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