PMID: 12766033May 27, 2003

Ocular measurements throughout the adult life span of rhesus monkeys

Investigative Ophthalmology & Visual Science
Alcides FernandesJames G Herndon


To examine the relationship of ocular components to refraction throughout the adult life span of the rhesus monkey (Macaca mulatta). Cycloplegic retinoscopy, A-scan ultrasonography, slit lamp examination, indirect ophthalmoscopy, and keratometry were performed in a cross-sectional study of 111 monkeys, aged 5 to 31 years. Lens thickness and anterior and vitreous chamber depths were measured from the echograms. The intercorrelations of these variables were analyzed, as well as their association with age and sex. In monkeys aged 5 to 15 years, the mean refractive value of +1.5 D with an SD of 1.7 D was maintained near the previously established developmental asymptote of +2 D. In monkeys older than 15 years, there was greater interindividual variation (SD = 4.5 D), including extreme myopia and hyperopia. The cornea became steeper with age. The axial length of the eyes increased up to 12 years of age and began to shorten after 20 years. Changes also occurred in the other individual components that constitute eye length. These age-related changes were decreased vitreous chamber depth, decreased anterior chamber depth, and increased lens thickness. In general, males had longer eyes than females. The eyes of old monkeys were more lik...Continue Reading


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Related Concepts

Anterior Chamber of Eye Structure
Prevalence Studies
Lens, Crystalline
Macaca mulatta
Ocular Refraction
Vitreous Body Structure

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