Ocular metastases secondary to carcinoid tumors: the utility of imaging with [(123)I]meta-iodobenzylguanidine and [(111)In]DTPA pentetreotide

The Journal of Clinical Endocrinology and Metabolism
A M IsidoriG M Besser

Abstract

Ocular metastases from carcinoid tumors are considered rare. They can be the primary presentation of a carcinoid tumor or develop during the course of the disease. The extent of distant metastases from carcinoid tumors correlates with poor prognosis and survival; early detection of metastasis may change the overall management. Radiopharmaceutical-labeled imaging techniques have been widely applied for the detection and localization of such lesions based on isotope uptake by neuroendocrine tumors. Routine application of these imaging modalities may reveal previously unsuspected lesions and may also be used to help stage the disease and to identify patients who may be treated with radiopharmaceuticals. Of 40 patients with carcinoid tumors reviewed in our department since we started routine scanning, we identified 6 (15%) who demonstrated ocular metastases: 5 with obvious lesions and 1 with presumed metastasis according to the results of nucleotide scanning. All 6 were negative on screening with [(123)I]meta-iodobenzylguanidine, whereas 3 of 4 who were screened with [(111)In]octreotide showed positive uptake. All patients responded well to radiotherapy and chemotherapy and did not require surgical treatment. The orbit and its cont...Continue Reading

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Citations

Sep 7, 2004·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Vasuki SivagnanavelMuriel Buxton-Thomas
Jun 10, 2006·Seminars in Nuclear Medicine·Vittoria RufiniRichard P Baum
May 1, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rebecca DobsonDaniel J Cuthbertson
Sep 18, 2018·Clinical Nuclear Medicine·Yin Jie Chen, Michael D Farwell
Nov 22, 2008·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Mohannad IbrahimHemant Parmar
Jun 8, 2004·Endocrine Reviews·Gregory A KaltsasAshley B Grossman
Mar 23, 2006·Molecular Biology and Evolution·Julien GrassotGuy Mouchiroud
Feb 1, 2011·Expert Opinion on Therapeutic Targets·Mehtap Cakir, Ashley Grossman
Jun 5, 2020·Ophthalmic Plastic and Reconstructive Surgery·Hamzah MustakDaniel Rootman
Nov 18, 2021·European Journal of Ophthalmology·Giorgio AlbaneseRaghavan Sampath

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