PMID: 11321616Apr 26, 2001Paper

Ocular motor delayed-response task performance among patients with schizophrenia and their biological relatives

Psychophysiology
J E McDowellB A Clementz

Abstract

Schizophrenia patients and their relatives have saccadic abnormalities characterized by problems inhibiting a response. The dorsolateral prefrontal cortex and its associated circuitry ostensibly mediate inhibition and support correct delayed response performance. In this context, two components of delayed response task performance are of interest: memory saccade metrics and error saccades made during the delay. To evaluate these variables, an ocular motor delayed response task was presented to 23 schizophrenia patients, 25 of their first-degree biological relatives, and 19 normal subjects. The measure that best differentiated groups was an increased frequency of error saccades generated during the delay by schizophrenia subjects and relatives. Decreased memory saccade gain also characterized patients and relatives. The similar pattern of results demonstrated by the patients with schizophrenia and their relatives suggests that performance on ocular motor delayed response tasks, either alone or in combination with other saccadic variables, may provide useful information about neural substrates associated with a liability for developing schizophrenia.

Citations

May 31, 2012·European Archives of Psychiatry and Clinical Neuroscience·Lisa KloftNorbert Kathmann
Jul 17, 2001·Biological Psychology·J E McDowell, B A Clementz
May 2, 2008·Schizophrenia Bulletin·S Kristian HillJohn A Sweeney
Feb 21, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Gerard Marek, Kalpana Merchant
Apr 13, 2005·The International Journal of Neuroscience·Indira TendolkarJoachim Klosterkötter
Oct 28, 2008·Brain and Cognition·Diane C Gooding, Michele A Basso
Jan 24, 2007·Schizophrenia Research·Alison R YungPatrick D McGorry
Jul 13, 2005·Psychophysiology·Ulrich EttingerPhilip J Corr
Nov 30, 2005·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Randal G RossAllen Radant
Mar 1, 2013·Early Intervention in Psychiatry·Tonya WhiteCanan Karatekin
Feb 22, 2005·Neuropsychologia·Florence ChanDouglas P Munoz
Sep 15, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Thomas A Ban
Oct 7, 2006·Schizophrenia Research·Allen D RadantDebby W Tsuang
Feb 7, 2006·Biological Psychiatry·Jazmin CamchongJennifer E McDowell
Dec 2, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Vaibhav A DiwadkarMatcheri S Keshavan
Feb 13, 2002·Biological Psychiatry·Jennifer E McDowellDavid L Braff
Sep 19, 2016·Schizophrenia Research·Simona CaldaniIsabelle Amado
May 25, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Heather C WhalleyStephen M Lawrie

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