Ocular motor dysfunction in HIV-1-infected subjects: a quantitative oculographic analysis

Neurology
J L JohnstonA Nath

Abstract

We recorded eye and head movements in 13 human immunodeficiency virus type-1 (HIV-1)-infected patients with CD4 counts of less than or equal to 500 cells/mm3 using magnetic search coil oculography. Horizontal and vertical saccades, smooth pursuit, and vestibular smooth eye movements were recorded, as were horizontal antisaccades and vestibular memory-guided saccades. Rightward and leftward and upward and downward responses were analyzed separately. Compared to normal control subjects, HIV-1--infected patients performed the antisaccade test poorly, making the initial antisaccade in the correct direction (away from the target) in only 33% of trials. The mean final gaze position achieved during the vestibular memory-guided saccade task was less accurate for HIV-1-infected patients than for control subjects, and this correlated with inaccuracies on the antisaccade task. Horizontal saccades, horizontal and vertical smooth pursuit, and vestibular smooth eye movements were quantitatively normal. However, smooth pursuit showed directional asymmetries, vertically more than horizontally; horizontal and vertical unpredictable saccades were more inaccurate than predictable saccades; and vertical saccade latencies were prolonged. In patient...Continue Reading

Citations

Feb 5, 2004·Current Treatment Options in Neurology·Avindra Nath, Joseph Berger
Sep 18, 1998·Neuropsychologia·S Everling, B Fischer
Dec 1, 2006·Schizophrenia Bulletin·Bruce I TuretskyNeal R Swerdlow
Oct 19, 2004·The British Journal of Ophthalmology·J-C MwanzaG T Plant
Oct 23, 2013·Auris, Nasus, Larynx·Barbara M HeinzeDe Wet Swanepoel
May 1, 1999·Journal of Neurosurgery·M D TaylorJ G Cairncross
Jan 22, 2020·Ocular Immunology and Inflammation·Lynn K Gordon, Helen Danesh-Meyer
Jan 1, 2017·Expert Review of Ophthalmology·Sushant Puri, Aasef G Shaikh

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