Ocular outcome and frequency of neurological manifestations in patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE).

Journal of Ophthalmic Inflammation and Infection
Bettina C ThomasFriederike Mackensen

Abstract

The purpose of this study was to describe the visual prognosis as well as the frequency and clinical severity of central nervous system involvement in all acute posterior multifocal placoid pigment epitheliopathy (APMPPE) patients of one centre. A retrospective database review of all patients and a prospective clinical, ophthalmological and neurological follow-up, if possible, were conducted. Eighteen patients with APMPPE were included with a mean follow-up of 17.1 months. Thirteen patients participated in a follow-up exam. Visual acuity improved in 9 of 18 patients to a mean of 0.17 log minimum angle of resolution (MAR) in the worse eye and remained stable in eight patients (mean, 0.03 logMAR). In the majority of patients, the 30° static perimetry improved at follow-up compared to the initial exams. Still, in up to 50 to 60 %, small visual field defects persisted. Overall, 11 patients (61 %) showed neurologic symptoms of varying severity. The most common neurological symptom was headache in nine (50 %) patients. Other symptoms included paraesthesias, psychosis, vertigo, and, as the most severe complication, stroke due to cerebral vasculitis. Fifteen patients were treated with systemic corticosteroids. Visual prognosis is good ...Continue Reading

References

Jul 1, 1977·American Journal of Ophthalmology·J D Bullock, R L Fletcher
Dec 1, 1989·The British Journal of Ophthalmology·D F Williams, W F Mieler
Jan 1, 1988·The British Journal of Ophthalmology·D J DickA R Morley
Jun 1, 1988·Archives of Ophthalmology·C A WilsonR Sheppard
Dec 1, 1972·American Journal of Ophthalmology·S J Ryan, A E Maumenee
Dec 1, 1972·The British Journal of Ophthalmology·A F DeutmanA L Aan de Kerk
May 1, 1973·Archives of Ophthalmology·P J Fitzpatrick, D M Robertson
Oct 1, 1973·American Journal of Ophthalmology·W H AnnesleyJ A Shields
Aug 1, 1968·Archives of Ophthalmology·J D Gass
Apr 1, 1995·The British Journal of Ophthalmology·N P Jones
Nov 1, 1993·Journal of Neurology·H BewermeyerJ Assheuer
May 1, 1996·Stroke; a Journal of Cerebral Circulation·S ComuN A Busis
Dec 19, 2007·Ocular Immunology and Inflammation·Daniel C KlineJudith E Warner
Feb 18, 2009·Cephalalgia : an International Journal of Headache·B R SpencerD W Dodick
Jun 6, 2009·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Katie LuneauValérie Biousse
Aug 28, 2009·Case Reports in Medicine·Hélène MasséJean-François Charlin

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Citations

Dec 24, 2015·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·P P FangF G Holz
Jul 31, 2013·Progress in Retinal and Eye Research·Toke Bek
May 11, 2016·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M MaierN Feucht
May 18, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·W J BrownleeJ A Pereira
Mar 21, 2018·BMC Ophthalmology·Olivia XerriAntoine P Brézin
Mar 25, 2018·Practical Neurology·Zhaleh KhaleeliGordon T Plant
Aug 28, 2018·Retina·Anton M Kolomeyer, Alexander J Brucker
Aug 14, 2019·Molecular Reproduction and Development·Haoya ChangFusheng Quan
Aug 16, 2017·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Eva LenassiNatasa Vidovič Valentinčič
Feb 23, 2020·Ocular Immunology and Inflammation·Isil KutluturkMarion R Munk
Nov 8, 2016·Journal of Clinical Neurology·Hussein AlgahtaniBader Shirah
Nov 20, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Hashim Ali Khan, Muhammad Aamir Shahzad
Aug 12, 2014·Retina·Olga FurashovaThomas A Albini
Jun 21, 2013·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Benjamin K-T TsangCatriona McLean
Feb 15, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M MischkeB Wiechens
Sep 14, 2017·Ophthalmic Surgery, Lasers & Imaging Retina·Jens Ulrich WernerGabriele Elisabeth Lang
May 14, 2021·American Journal of Ophthalmology Case Reports·Shani PillarMichal Kramer
Jun 5, 2021·Journal of Vitreoretinal Diseases·Andrew W BrowneSunil K Srivastava
Apr 13, 2021·American Journal of Ophthalmology·UNKNOWN Standardization of Uveitis Nomenclature (SUN) Working Group
Sep 16, 2021·Journal of Ophthalmic Inflammation and Infection·Ilaria TestiCarlos Pavesio
Nov 26, 2019·Retinal Cases & Brief Reports·Michael E SulewskiAlexander J Brucker

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Methods Mentioned

BETA
biopsy

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