PMID: 6105048Apr 15, 1980Paper

Ocular penetration of beta-adrenergic blocking agents. An experimental study with atenolol, metoprolol, timolol and propranolol

Documenta Ophthalmologica. Advances in Ophthalmology
F E RosP A van Zwieten

Abstract

A comparison was made between the ocular penetration of topically applied 14C-atenolol, 14C-timolol, 14C-propranolol and 3H-metoprolol by means of liquid scintillation counting. Only one eye was treated, the fellow eye served as a control. Blood plasma levels were measured as well. We could detect a relationship between the ocular penetration and the degree of lipophilicity of the drugs used, as was to be expected. Drugs with a higher degree of lipophilicity penetrated more readily into the eye, whereas they also achieved higher blood plasma levels. Relatively high concentrations of atenolol were found in the nicitating membrane, thus reflecting its poor ocular penetration. The concentrations detected in the untreated eye were low and probably cannot explain the marked reduction in intraocular pressure observed after unilateral instillation of active beta-adrenergic blocking drugs, as for instance timolol. Our findings suggest that the ocular penetration of beta-adrenergic blocking agents on topical application only plays a minor part in their ocular hypotensive effect.

References

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Citations

Apr 21, 1998·Journal of Pharmaceutical and Biomedical Analysis·K D RittenhouseG M Pollack
Sep 1, 1981·The British Journal of Ophthalmology·C I PhillipsR Vogel
Mar 1, 1985·The British Journal of Ophthalmology·C I PhillipsR Vogel
Jan 6, 2012·Journal of Environmental and Public Health·Eliza Maria da Costa Brito LacerdaLuiz Carlos de Lima Silveira
Dec 17, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bjoern WagnerFrauke Assmus
Oct 9, 2007·Journal of Pharmaceutical Sciences·Yoshihisa Shirasaki
Jul 1, 1996·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·N von der OheH Brewitt
Sep 4, 2009·Electrophoresis·Garry D SiskDamien W M Arrigan
Jan 1, 1982·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·H C Innemee, P A van Zwieten
Jan 1, 1981·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·C SchmittJ C Le Douarec
Jan 1, 1991·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C KesslerG Kleintges
Jan 1, 1991·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C KesslerG Kleintges

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