PMID: 8951681Jan 1, 1996Paper

Ocular pharmacokinetics and convectional flow: evidence from spatio-temporal analysis of mydriasis

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics
H J Wyatt

Abstract

Pupil shape and placement were studied during pharmacologic dilation, using a photographic technique. Dilation onset was highly asymmetric; typically, the inferior or inferior-nasal side of the pupil moved maximally, while the opposite side barely moved. Pupil shape tended to elongate at a large angle to the direction of maximum shift. Late in dilation, pupils returned to more circular shape and pupil centers returned to near their original position. Results when a subject's head was inverted during and immediately after drug administration were essentially unchanged. However, results when a subject's head was rolled on one side (and kept there) after administration were markedly different; the dilation pattern shifted roughly in accord with head tilt. It is proposed that anterior chamber convectional flow is responsible for the asymmetry. Supportive evidence was obtained from experiments in which cooled or heated gel-packs were applied to the lids. Analysis indicates that convectional flow makes a very substantial contribution to anterior segment pharmacokinetics and is also likely to be of general importance in anterior segment transport.

References

Aug 1, 1991·Optometry and Vision Science : Official Publication of the American Academy of Optometry·H J Wyatt
Oct 1, 1970·Archives of Ophthalmology·K A Polse, R B Mandell
Apr 1, 1969·Experimental Eye Research·M V Riley
Jan 1, 1982·American Journal of Optometry and Physiological Optics·B A Weissman, I Fatt
Mar 1, 1995·American Journal of Ophthalmology·H FujishimaK Tsubota

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Citations

Jun 24, 2006·Bulletin of Mathematical Biology·A D Fitt, G Gonzalez
Jan 5, 2002·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·H J Wyatt, M Lustgarten
Apr 10, 2012·Journal of Biomechanical Engineering·Omid AboualiJiyuan Tu
Nov 21, 2007·Computers in Biology and Medicine·Ean-Hin Ooi, Eddie Yin-Kwee Ng
Aug 6, 2016·Scientific Reports·Umberto LuciaAntonio Ponzetto
Aug 10, 2004·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Yanjun Chen, Harry J Wyatt
Apr 21, 2004·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Harry J Wyatt

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