Ocular Photoreception for Circadian Rhythm Entrainment in Mammals

Annual Review of Vision Science
Russell N Van Gelder, Ethan Buhr

Abstract

Circadian rhythms are self-sustained, approximately 24-h rhythms of physiology and behavior. These rhythms are entrained to an exactly 24-h period by the daily light-dark cycle. Remarkably, mice lacking all rod and cone photoreceptors still demonstrate photic entrainment, an effect mediated by intrinsically photosensitive retinal ganglion cells (ipRGCs). These cells utilize melanopsin (OPN4) as their photopigment. Distinct from the ciliary rod and cone opsins, melanopsin appears to function as a stable photopigment utilizing sequential photon absorption for its photocycle; this photocycle, in turn, confers properties on ipRGCs such as sustained signaling and resistance from photic bleaching critical for an irradiance detection system. The retina itself also functions as a circadian pacemaker that can be autonomously entrained to light-dark cycles. Recent experiments have demonstrated that another novel opsin, neuropsin (OPN5), is required for this entrainment, which appears to be mediated by a separate population of ipRGCs. Surprisingly, the circadian clock of the mammalian cornea is also light entrainable and is also neuropsin-dependent for this effect. The retina thus utilizes a surprisingly broad array of opsins for mediatio...Continue Reading

References

Sep 1, 1972·The Journal of Comparative Neurology·R Y Moore, N J Lenn
Jan 1, 1973·Experimental Eye Research·Y Kikkawa
Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·R J Konopka, S Benzer
Oct 16, 1965·Nature·R B Mandell, I Fatt
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S J PittlerW Baehr
Jan 1, 1993·Annual Review of Physiology·C S Pittendrigh
Apr 19, 1996·Science·G Tosini, M Menaker
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·I ProvencioM D Rollag
Jun 6, 2000·Neuron·P EmeryM Rosbash
Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·C L ThompsonA Sancar
Feb 9, 2002·Science·David M BersonMotoharu Takao
Oct 3, 2002·Journal of Neurochemistry·Susan E DoyleMichael Menaker
Dec 14, 2002·Science·Norman F RubyBruce F O'Hara
Dec 14, 2002·Science·Satchidananda PandaSteve A Kay
Jan 1, 2003·Visual Neuroscience·Susan E DoyleMichael Menaker
Jan 11, 2003·Science·Russell N Van GelderDaniel C Tu
Mar 28, 2003·Journal of Neurophysiology·Erik D Herzog, Rachel M Huckfeldt
Jun 28, 2003·Science·Satchidananda PandaJohn B Hogenesch
Nov 19, 2003·FEBS Letters·Emma E TarttelinRobert J Lucas
Dec 19, 2003·Chronobiology International·N Mrosovsky, S Hattar
Feb 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Seung-Hee YooJoseph S Takahashi
Mar 11, 2004·Brain Research. Molecular Brain Research·Carol L ThompsonAziz Sancar
Aug 4, 2004·Journal of Neurochemistry·Katsuhiko SakamotoGianluca Tosini
Oct 2, 2004·Science·Daniel C TuRussell N Van Gelder
Oct 29, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Katsuhiko SakamotoGianluca Tosini
Nov 4, 2004·Journal of Biological Rhythms·Carol L ThompsonAziz Sancar
Feb 1, 2005·Science·Satchidananda PandaTim Jegla
Jun 28, 2005·Investigative Ophthalmology & Visual Science·Joseph A BrzezinskiTom Glaser
Jul 12, 2005·Experimental Eye Research·Tida Kumbalasiri, Ignacio Provencio
Jul 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yingbin FuKing-Wai Yau
Sep 16, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·N Mrosovsky, S Hattar
Feb 21, 2006·Current Biology : CB·Alun R BarnardRobert J Lucas

❮ Previous
Next ❯

Citations

Nov 8, 2018·The European Journal of Neuroscience·Vania Carmona-AlcocerJennifer A Evans
Nov 8, 2017·The Journal of Biological Chemistry·Jeremy D CookGabriel H Travis
Jun 17, 2020·Investigative Ophthalmology & Visual Science·Nicolás M DíazEthan D Buhr
May 20, 2017·Annual Review of Neuroscience·Lorenzo Lazzerini OspriSamer Hattar
May 24, 2018·Current Neurology and Neuroscience Reports·Jacqueline F YatesDavid G Ingram
Jan 19, 2018·Clinical and Molecular Allergy : CMA·Roberto PaganelliMario Di Gioacchino
Mar 17, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Umut ArslanFigen Şermet
Apr 29, 2020·Antioxidants·Justyna GodosGiuseppe Grosso
Mar 12, 2021·Journal of Applied Physiology·Iain TemplemanJames A Betts
Aug 16, 2019·Brain, Behavior and Evolution·Georg F Striedter

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Ethan Buhr, Russell N Van Gelder
Investigative Ophthalmology & Visual Science
Leah OwensRussell N Van Gelder
© 2022 Meta ULC. All rights reserved