Ocular side effects of antirheumatic medications: a qualitative review

BMJ Open Ophthalmology
Clara M Castillejo BecerraAlexa Simon Meara

Abstract

This paper reviews the ocular side effects of medications used in the treatment of rheumatological conditions. Rheumatic diseases are inflammatory conditions that may affect the skin, blood vessels, joints, muscles and internal organs. Immunosuppressive agents are often used as treatment and while powerful, they carry side effects and toxicities that need careful monitoring. Ophthalmic complications have been reported with the use of antirheumatic medications; however, there is a lack of literature synthesising these reports. This paper addresses this gap and hopes to inform both rheumatologists and ophthalmologists as they work together on the management of patients with rheumatological conditions. PubMed literature search was conducted from November to September 2019 searching for ocular side effects with the use of 25 rheumatological drugs. A total of 111 papers were included in this review. Adverse side effects were divided into non-infectious and infectious causes. Traditional disease-modifying antirheumatic drugs (DMARDs) were associated with pruritus, irritation and dryness of the conjunctiva while biologic DMARDS showed reports of new-onset/recurrent uveitis and demyelinating conditions. Infectious side effects included...Continue Reading

References

Jan 1, 1992·Documenta Ophthalmologica. Advances in Ophthalmology·B A Johansson
Jan 1, 1990·Cancer Investigation·C L LoprinziM M Ames
Dec 21, 1989·The New England Journal of Medicine·B D Kahan
Dec 1, 1981·American Journal of Ophthalmology·F E Lepore, M J Nissenblatt
Sep 1, 1981·International Journal of Dermatology·A R Ahmed, R Moy
Jul 6, 2000·Immunopharmacology·A C Allison, E M Eugui
Oct 29, 2000·Annals of the Rheumatic Diseases·F C Breedveld, J M Dayer
Jun 1, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·H Openshaw
Nov 13, 2002·Clinical & Experimental Ophthalmology·Chandra BalachandranG Michael Halmagyi
Jan 25, 2003·The British Journal of Ophthalmology·K L TuS Harding
May 10, 2003·The American Journal of Gastroenterology·Srinivas R Puli, David D Benage
Jun 5, 2003·Japanese Journal of Ophthalmology·Takako NakamuraRyuzo Tsugawa
Nov 19, 2003·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·J Santodomingo-RubidoJ S Wolffsohn
Jan 24, 2004·Rheumatology·A BarakI Schwab
May 19, 2004·The British Journal of Ophthalmology·L J Clifford, J D Rossiter
Oct 21, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Georg HaerterMichael Schmitt
Jun 7, 2005·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Gerry ClareJohn S Elston
Oct 20, 2005·Clinical Pharmacokinetics·Milly E de JongeJos H Beijnen
Jan 5, 2006·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Kamilia RizkallaJ Godfrey Heathcote
Feb 16, 2006·Archives of Ophthalmology·Frederick W FraunfelderThomas J Mehelas
Mar 28, 2006·American Journal of Ophthalmology·Jonathan C P Roos, Andrew J K Ostor
Apr 29, 2006·Arthritis and Rheumatism·In-Sook J ShinJeffrey N Siegel
Jul 29, 2006·World Journal of Gastroenterology : WJG·Luciana Lofego GoncalvesFlair José Carrilho
Aug 29, 2006·World Journal of Gastroenterology : WJG·Iman ZandiehEric M Yoshida
Oct 28, 2006·Seminars in Arthritis and Rheumatism·Slim LassouedThierry Billey
Nov 30, 2006·Nature Clinical Practice. Rheumatology·Eric M Ruderman, Richard M Pope
Apr 26, 2007·Annals of the Rheumatic Diseases·Ismail SimsekAyhan Dinc
Apr 26, 2007·Indian Journal of Ophthalmology·Pankaj Kumar AgarwalMeena Virdi
May 19, 2007·The British Journal of Ophthalmology·Akio OishiNagahisa Yoshimura
Jun 26, 2007·World Journal of Gastroenterology : WJG·Damien SenePatrice Cacoub
Jul 5, 2007·The Annals of Pharmacotherapy·Mark A Marinella
Feb 2, 2008·Eye·P Arriola-VillalobosJ M Benítez-del-Castillo
May 10, 2008·European Journal of Gastroenterology & Hepatology·Sundaram G VeerappanBarbara M Ryan
Aug 15, 2008·Clinical & Experimental Ophthalmology·Helen H-J DoJohn Grigg
Sep 17, 2008·European Journal of Gastroenterology & Hepatology·Miguel AreiaMaximino Correia Leitão
Feb 6, 2009·American Journal of Clinical Oncology·Alan J RodneyNizar M Tannir
Sep 19, 2009·Japanese Journal of Ophthalmology·Jun Suzuki, Hiroshi Goto

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Citations

Apr 1, 2021·International Ophthalmology·Yihui GohSujaya Singh
Jun 4, 2021·Survey of Ophthalmology·Menelaos KanakisIlias Georgalas
Aug 3, 2021·Journal of Tissue Engineering and Regenerative Medicine·Letícia E CharelliTiago A Balbino
Nov 4, 2021·American Journal of Clinical Dermatology·Mahsaw MotlaghBobeck S Modjtahedi

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