Ocular side effects of deferoxamine therapy in aplastic anemia with transfusion-induced hemochromatosis

Klinische Monatsblätter für Augenheilkunde
C W SpraulG E Lang

Abstract

Deferoxamine, an iron chelating agent, has been used for the treatment of hemochromatosis for more than 30 years. Ocular toxicity has begun to be reported only in the last few years. In most cases differentiation of the true etiology, i.e. the underlying disease versus the toxicity of the substance, is not clear. We report a patient with development of severe ocular toxicity during treatment with deferoxamine for transfusional hemochromatosis. An 8-year-old boy was routinely evaluated in the eye clinic before initiation of treatment with deferoxamine. Over the last three years the boy had developed a transfusional hemochromatosis after multiple blood transfusions for his aplastic anemia. Ophthalmologic examination displayed normal anterior segments with the exception of a unilateral small opacification of the posterior lens cortex, bilateral tortuous vessels, and mottling of the retinal pigment epithelium. After four months the patient developed a decrease in visual acuity, distortion of color vision, visual field defects, alteration of electrophysiological parameters, and severe changes of the retinal pigment epithelium. The deferoxamine was discontinued. Over a period of 3 months the patient displayed a normalization of visua...Continue Reading

Citations

Jul 30, 2004·American Journal of Hematology·Anita AroraKevin Gregory Evans
Feb 3, 2016·International Journal of Hematology·Somayeh KalanakyMohammad Hassan Nazaran

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