Ocular surface analysis in hematological patients before and after allogeneic hematopoietic stem cell transplantation: implication for daily clinical practice

Eye
Giuseppe GiannaccareE C Campos

Abstract

PurposeTo evaluate ocular surface parameters before and after hematopoietic stem cell transplantation (HSCT) and to correlate them with clinical and transplant variables.MethodsThis is a retrospective analysis of data from 93 patients affected by hematological malignancies undergoing HSCT. Values from Ocular Surface Disease Index, Schirmer test, Break-up Time, ocular surface staining, and Meibomian Gland Dysfunction score obtained before HSCT and 3-6 months after were retrieved from charts. Diagnosis and staging of dry eye (DE) disease was performed according to Dry Eye WorkShop criteria. Graft-versus-host-disease (GVHD) was classified according to the NIH criteria. Odds ratios for DE onset after HSCT were estimated for demographic, ocular, hematological and transplant variables.ResultsDE was diagnosed before HSCT in 50 (53%) of the patients, mostly of hyperevaporative profile. After HSCT, all ocular parameters significantly worsened with no change in DE profile. A 51% incident cases (22 of the 43 non-DE subjects) were reported. Increasing recipient age and female sex, higher CD34+ cells infused, donor-recipient sex mismatch (males receiving from females), related donors, and peripheral blood cells as stem cell source were asso...Continue Reading

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Citations

Nov 28, 2018·Investigative Ophthalmology & Visual Science·Yoko Ogawa
Dec 21, 2019·Translational Vision Science & Technology·Marc PellegriniGiusepp Giannaccare
Jan 29, 2021·Journal of Cellular Physiology·Alice BruscoliniAlessandro Lambiase
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Apr 30, 2021·Indian Journal of Ophthalmology·Swapna S Shanbhag, Sayan Basu
Sep 21, 2021·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Jelena Marie KezicMariapia Degli-Esposti

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