Ocular surface changes following oral anticholinergic use for overactive bladder

Cutaneous and Ocular Toxicology
Mehmet Ali SekerogluUmut Arslan

Abstract

To investigate the effect of oral solifenacin succinate on Schirmer I test results, tear break-up time (TBUT) and Ocular Surface Disease Index (OSDI) scores in overactive bladder (OAB) patients and to compare these results with those of healthy control subjects. The female OAB patients who were prescribed oral solifenacin succinate 5 mg/day (Group I, N = 80) and age-matched healthy female subjects (Group II, N = 40) were recruited for the study and underwent ophthalmological examination prior to oral treatment and after 4 weeks. They completed the OSDI questionnaire and underwent ocular surface tests including Schirmer I test and TBUT. The statistical analysis of the Schirmer I test and TBUT revealed no significant difference between the baseline and 4th week values in both groups (Group I, p = 0.506 and p = 0.070 consecutively) (Group II, p = 0.810 and p = 0.823 consecutively). OSDI scores were found to be significantly increased in group I (21.8 ± 4.2 vs 23.1 ± 4.6, p = 0.020) and remained unchanged in group II (20.5 ± 7.0 vs 20.7 ± 7.0, p = 0.805). Short-term solifenacin succinate treatment has no effect on the Schirmer I test results and TBUT, but ocular surface symptoms appeared to be exacerbated in respect with increased ...Continue Reading

References

May 18, 2000·Archives of Ophthalmology·R M SchiffmanB L Reis
Feb 1, 2003·Urology·Paul AbramsUNKNOWN Standardisation Sub-Committee of the International Continence Society
Dec 25, 2003·Lancet Neurology·Karl-Erik Andersson
Apr 22, 2005·British Journal of Clinical Pharmacology·R Altan-YayciogluH Ozkardes

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Citations

Feb 6, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Mahmut Taha OlcucuYusuf Cem Yilmaz

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