Ocular Surface Disease in Glaucoma: Effect of Polypharmacy and Preservatives

Optometry and Vision Science : Official Publication of the American Academy of Optometry
Norlina RamliMay May Choo

Abstract

To evaluate the prevalence of ocular surface disease (OSD) in glaucoma and nonglaucoma subjects using different clinical tests and to determine the effect of number of antiglaucoma medications and preservatives on OSD. This is a cross-sectional, case-comparison study at the Eye Clinic of the University of Malaya Medical Centre, Malaysia, between June 2012 and January 2013. Glaucoma subjects (n = 105) using topical antiglaucoma medications were compared with control subjects (n = 102) who were not on any topical medications. The presence of OSD was assessed using the tear film breakup time (TBUT) test, corneal staining, Schirmer test, and Ocular Surface Disease Index (OSDI) questionnaire grading. The prevalence of OSD varied from 37 to 91% in the glaucoma group, depending on the type of clinical test. More subjects in the glaucoma group had corneal staining (63% vs. 36%, p = 0.004), abnormal Schirmer tests (39% vs. 25%, p = 0.049), and moderate OSDI symptoms (17% vs. 7%, p = 0.028). The percentage with abnormal TBUT increased with higher numbers of topical medications and was high with both benzalkonium chloride-containing and preservative-free eye drops (90% and 94%, respectively, both p < 0.001). Benzalkonium chloride was asso...Continue Reading

Associated Clinical Trials

References

Apr 1, 1994·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C de JongJ van Best
May 18, 2000·Archives of Ophthalmology·R M SchiffmanB L Reis
Jan 11, 2002·Advances in Therapy·R Noecker
Mar 27, 2002·The British Journal of Ophthalmology·P J PisellaC Baudouin
Apr 8, 2004·Clinical & Experimental Ophthalmology·Seung-Heon ChaChi-Dae Kim
Apr 16, 2004·Cornea·Kelly K NicholsKarla Zadnik
Aug 16, 2008·Journal of Glaucoma·Eamon W LeungRobert N Weinreb
Jul 16, 2010·Investigative Ophthalmology & Visual Science·Benjamin D SullivanMichael A Lemp
Apr 20, 2011·Current Eye Research·William C StewartLindsay A Nelson
Sep 29, 2011·Investigative Ophthalmology & Visual Science·Bradley E DoughertyKelly K Nichols
Mar 8, 2012·Clinical & Experimental Ophthalmology·Sudipta GhoshJonathan G Crowston
May 30, 2013·Ophthalmology·Priya M MathewsEsen K Akpek

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Citations

Mar 30, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ngamkae RuangvaravateRatchadaporn Tantimala
Jun 6, 2018·International Ophthalmology Clinics·Kristin Schmid Biggerstaff, Albert Lin
Sep 11, 2018·Eye & Contact Lens·Xuemin ZhangOsamah Saeedi
Sep 27, 2016·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Sang Yeop LeeChan Yun Kim
Mar 23, 2019·Journal of Current Ophthalmology·Kofi Asiedu, Sampson Listowell Abu
Aug 25, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Meng C LinKenneth A Polse
May 16, 2018·Journal of Glaucoma·Tomas Bro, Christina Lindén
Aug 23, 2020·Pharmaceutics·Baptiste BertonValérie Sautou
Jan 13, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Chien-Chia SuPeter Richmond Candano Lee
Dec 17, 2020·Asia-Pacific Journal of Ophthalmology·Lisa M NijmMinas Theodore Coroneo
Oct 6, 2021·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Jo-Hsuan WuChien-Chia Su

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