Ocular Surface Disease in Patients under Topical Treatment for Glaucoma

European Journal of Ophthalmology
Francisco Pérez-BartoloméJulián García-Feijoó

Abstract

To examine the relationship between ocular surface disease (OSD) and topical antiglaucoma therapy. A total of 211 eyes of 211 patients with open-angle glaucoma or ocular hypertension on topical medication were recruited over 10 months. Controls were 51 eyes of 51 healthy age- and sex-matched volunteers. In each patient, we recorded the intraocular pressure-lowering eyedrops used, the number of medications used, and daily and cumulative preservative concentrations (PC). Main outcome measures were fluorescein corneal staining score (Oxford scale), lower tear meniscus height (LTMH) (spectral-domain optical coherence tomography), noninvasive tear film breakup time (NI-TBUT) (Oculus Keratograph 5M), and OSD symptom questionnaire index (OSDI). Compared to controls, significantly higher OSDI (median [interquartile range] 10.24 [4.54-18.94] vs 2.5 [0-12.5]; p<0.001) and corneal staining (≥1: 64.93% vs 32.61%; p<0.001) scores were recorded in the medication group. The NI-TBUT and LTMH failed to vary between the groups (p>0.05). A higher daily PC was associated with a lower LTMH (R -0.142; p = 0.043). In the medication group, multivariate analysis identified correlations between benzalkonium chloride (BAK) (odds ratio [OR] 1.56) and BAK ...Continue Reading

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References

May 1, 1996·The British Journal of Ophthalmology·H A Quigley
May 18, 2000·Archives of Ophthalmology·R M SchiffmanB L Reis
Oct 6, 2001·Survey of Ophthalmology·H Brewitt, F Sistani
Mar 27, 2002·The British Journal of Ophthalmology·P J PisellaC Baudouin
Apr 27, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pascal FurrerRobert Gurny
Apr 6, 2005·American Journal of Ophthalmology·Vassilios P KozobolisAnastasios G Konstas
Feb 9, 2007·Acta Ophthalmologica Scandinavica·Anand ChawlaMark Batterbury
Feb 24, 2007·American Journal of Ophthalmology·Biljana MiljanovićDebra A Schaumberg
Sep 18, 2007·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Etty BittonLyndon Jones
Apr 15, 2008·Arquivos brasileiros de oftalmologia·Lina do Prado BaffaEduardo Melani Rocha
Aug 16, 2008·Journal of Glaucoma·Eamon W LeungRobert N Weinreb
Jun 25, 2009·European Journal of Ophthalmology·Gemma Caterina Maria RossiPaolo Emilio Bianchi
Sep 24, 2009·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Sheng ZhouDavid Huang
Apr 20, 2011·Current Eye Research·William C StewartLindsay A Nelson
May 12, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Cristiana ValenteMaurizio Rolando
Aug 30, 2011·American Journal of Ophthalmology·Simon E SkalickyPeter McCluskey
Sep 9, 2011·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Ethan H TittlerDavid Huang
Sep 29, 2011·Investigative Ophthalmology & Visual Science·Bradley E DoughertyKelly K Nichols
Feb 22, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Reiko AritaShiro Amano
Mar 8, 2012·Clinical & Experimental Ophthalmology·Sudipta GhoshJonathan G Crowston
May 30, 2013·Ophthalmology·Priya M MathewsEsen K Akpek
Oct 14, 2014·Acta Ophthalmologica·Shizuka KohKohji Nishida
Oct 25, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Weizhong LanMinbin Yu
Feb 14, 2015·The British Journal of Ophthalmology·Pedro Arriola-VillalobosJosé M Benítez-Del-Castillo
Mar 5, 2015·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Andrew CampAnat Galor
Apr 13, 2015·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Celine E SaadeAlbert S Khouri
Apr 29, 2015·Clinical Ophthalmology·Barbara CvenkelMargareta Strojan Fležar

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Citations

Jun 4, 2019·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Nery García-PortaShahina Pardhan
May 18, 2019·Current Medicinal Chemistry·Gloria RobertiFrancesco Oddone
Nov 18, 2017·Seminars in Ophthalmology·Francisco Pérez BartoloméJulián García Feijoó
Nov 27, 2019·International Journal of Environmental Research and Public Health·Siu-Fung ChauChia-Yi Lee
Jun 6, 2018·International Ophthalmology Clinics·Kristin Schmid Biggerstaff, Albert Lin
Sep 25, 2020·Journal of Glaucoma·Ioannis HalkiadakisVasiliki Konstadinidou
Jan 13, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Chien-Chia SuPeter Richmond Candano Lee
Jan 23, 2021·Expert Opinion on Drug Safety·Anastasios G KonstasChristophe Baudouin
Mar 11, 2021·Clinical Ophthalmology·Carl ErbFrancisco José Muñoz-Negrete
Oct 6, 2021·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Jo-Hsuan WuChien-Chia Su
Oct 13, 2021·Korean Journal of Ophthalmology : KJO·Kyung Joo MaengChan Yun Kim

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