Ocular surface manifestation of COVID-19 and tear film analysis

Scientific Reports
Alessandro MeduriPasquale Aragona

Abstract

To evaluate the ocular manifestation in patients hospitalized with coronavirus disease 2019 (COVID-19) and to search for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in tears. This study was conducted in 29 hospitalized patients who were admitted to the COVID center at the Policlinic Hospital of the University of Messina, Italy. All patients underwent an ophthalmologic assessment comprising a Standardized Patient Evaluation of Eye Dryness (SPEED) questionnaire, anterior segment, and the ocular surface examination of both eyes using a portable slit lamp. The Schirmer I test was performed, and the filter paper strip was used to search for the presence of SARS-CoV-2 on the ocular surface by real-time quantitative polymerase chain reaction (RT-qPCR). A total of 10 patients reported ocular symptoms; in particular, four reported eye burning, three reported foreign body sensation, and three reported tearing. Moreover, seven patients presented conjunctival hyperemia and/or chemosis, eleven patients presented blepharitis signs such as lid margin hyperemia and/or telangiectasia, crusted eyelashes, and meibomian orifices alterations. Tear analysis did not reveal the presence of SARS-CoV-2. Ocular symptoms a...Continue Reading

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Citations

Jan 26, 2021·Curēus·Abhimanyu S AhujaManisha Salinas
Feb 23, 2021·Computational and Structural Biotechnology Journal·Jiawei ShenXinyi Xia
May 14, 2021·Ocular Immunology and Inflammation·Ayten GunduzOzlem Cagasar
May 15, 2021·Eye & Contact Lens·Shizuka Koh, Michelle K Rhee
Jul 1, 2021·BMJ Open Ophthalmology·Astrid MuyldermansPeter P M Raus
Aug 8, 2021·Journal of Clinical Medicine·Dominika SzkodnyAdam Wylęgała
Sep 1, 2021·Ocular Immunology and Inflammation·Sertaç Argun Kivanç, Berna Akova
Oct 15, 2021·Ocular Immunology and Inflammation·Arif Ülkü Yener
Nov 12, 2021·International Ophthalmology·Seyed Hashem DaryabariHossein Aghamollaei

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Methods Mentioned

BETA
Assay

Software Mentioned

SPSS

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