Ocular surface mucins and local inflammation-studies in genetically modified mouse lines

BMC Ophthalmology
Kumi Shirai, Shizuya Saika

Abstract

Mucins locate to the apical surfaces of all wet-surfaced epithelia including ocular surface. The functions of the mucins include anti-adhesive, lubrication, water retention, allergens and pathogen barrier function. Ocular surface pathologies, i.e. dry eye syndrome or allergic conjunctivitis, are reportedly associated with alteration of expression pattern of mucin components. Recent investigations indicated anti-bacterial adhesion or anti-inflammatory effects of members of mucins in non-ocular tissues, i.e., gastrointestinal tracts or airway tissues, by using genetically modified mouse lines that lacks an expression of a mucin member. However, examination of ocular phenotypes of each of mucin gene-ablated mouse lines has not yet fully performed. Muc16-dficient mouse is associated with spontaneous subclinical inflammation in conjunctiva. The article reviews the roles of mucin members in modulation of local inflammation in mucous membrane tissues and phenotype of mouse lines with the loss of a mucin gene. Analysis of ocular surface of mucin-gene related mutant mouse lines are to be further performed.

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Citations

Jan 11, 2018·Pathogens·Richard J O'Callaghan
Sep 7, 2019·International Journal of Environmental Research and Public Health·Tae Gu LeeChan-Sik Kim
Sep 10, 2017·Apoptosis : an International Journal on Programmed Cell Death·Yoon-Ju NaKi Young Kim
Apr 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chae Eun KimJaewook Yang

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Methods Mentioned

BETA
PCR
transgenic

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