Ocular surface squamous neoplasia: analysis based on the 8th American Joint Committee on Cancer classification

International Ophthalmology
Swati SinghSwathi Kaliki

Abstract

To evaluate outcomes of ocular surface squamous neoplasia (OSSN) based on American Joint Committee on Cancer (AJCC), 8th edition classification. Retrospective, non-randomized interventional case series of 127 patients (136 eyes) with OSSN. On the basis of the AJCC (eighth edition), OSSN was classified as per T category as Tis (n = 14, 10%), T1 (n = 0), T2 (n = 4, 3%), T3 (n = 113, 83%), and T4 (n = 5, 4%). The following parameters increased with increasing T category: mean age at presentation at 37 years for Tis, 43 years for T2, 46 years for T3, and 55 years for T4 (p = 0.04); mean tumor basal diameter of 4 mm for Tis, not applicable (na) for T1, 6 mm for T2, 7 mm for T3, 20 mm for T4 (p = 0.001); extent of clock hours of corneal involvement (0, na, 0, 4, 8; p = 0.02), and conjunctival involvement (1, na, 2, 3, 9; p = 0.0005); involvement of adjacent structures including fornix (0%, na, 0, 9, 80%; p < 0.001), and caruncle (0%, na, 0, 3, 60%; p < 0.001) for Tis, T1, T2, T3, and T4, respectively. Overall, of the 136 eyes, 19 (14%) had tumor recurrence, and all tumor recurrences were seen in T3. Regional lymph node metastasis was noted in 4 (3%) patients. No systemic metastasis or death occurred in any patient during the mean fol...Continue Reading

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Citations

Feb 3, 2019·The British Journal of Ophthalmology·Martina C Herwig-CarlClaudia Auw-Haedrich
Jan 18, 2020·The British Journal of Ophthalmology·Rami DarwichIvan V Litvinov
Sep 26, 2020·Indian Journal of Ophthalmology·Akshay Gopinathan NairVandana Jain
Jul 22, 2018·Ophthalmology and Therapy·Maria Vittoria CicinelliGiulio Modorati
Nov 25, 2019·Ophthalmology and Therapy·Victoria M L Cohen, Roderick F O'Day

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