Ocular symptoms and signs associated with suramin sodium treatment for metastatic cancer of the prostate

American Journal of Ophthalmology
R K HemadyM A Eisenberger

Abstract

Therapy with suramin sodium has been associated with photophobia, iritis, optic atrophy, and vortex keratopathy. We studied the ocular findings in patients who underwent treatment with suramin sodium for metastatic cancer of the prostate. In a prospective study, 114 patients who underwent treatment with suramin sodium for cancer of the prostate had an ophthalmologic examination with two weeks of onset of treatment and two weeks after termination of therapy. Additional examinations were performed on patients who developed ocular symptoms during suramin sodium therapy. Nineteen (16.6%) of 114 patients developed ocular symptoms and signs while taking suramin sodium. Thirteen of these patients developed bilateral corneal epithelial whorllike deposits. In ten patients, the corneal deposits were associated with foreign body sensation and lacrimation. Symptoms in all of these patients resolved with topical lubricants. Three patients developed asymptomatic corneal deposits. Seven patients had blurred vision and were found to have a mean hyperopic shift in refractive error of 1.13 +/- 0.45 diopters (range, 0.75 to 2.00 diopters) that persisted throughout their treatment course. None of these patients had a decrease in best-corrected vis...Continue Reading

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Citations

Jan 25, 2002·Biophysical Journal·Nicole LehmannKarim Fahmy
Oct 13, 2020·Frontiers in Pharmacology·Chandan SarkarDaniela Calina
Jun 19, 2021·Bioorganic Chemistry·Jayanta DowarahVed Prakash Singh

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