Ocular toxicity of intravitreal melphalan for retinoblastoma in Chinese patients

BMC Ophthalmology
K XueJ Qian

Abstract

To evaluate the efficacy, complications, and clinical characteristics, including the ocular toxicity, of intravitreal melphalan(IVM) treatment for vitreous seeding in Chinese retinoblastoma patients. This was a retrospective, non-comparative analysis including 30 consecutive eyes of 23 patients with viable persistent or recurrent vitreous seeding following retinoblastoma treatment. All of the eyes received IVM injections (20-33 μg). Vitreous seeding control, determination of the ocular toxicity, and the clinical characteristics of intravitreal melphalan treatments were observed. The mean patient age at the time of the injection was 28 months (median = 22 months, range = 12-50 months). In total, 80 injections were administered in 30 eyes, the overall enucleation-free survival rate was 83.3% (25/30). The complications included retinal pigment epithelium (RPE) and choroidal atrophy (19/30, 63.3%), pupillary synechiae (13/30, 43.3%), iris atrophy (12/30, 40%), retinal vascular occlusion (12/30, 40.0%), optic atrophy (6/30, 20%), vitreous hemorrhage (3/30, 10%), persistent hypotonia and phthisis bulbi (4/30 13.3%), and cataracts (8/30, 26.6%). Twelve eyes demonstrated grade 3 or greater IVM-associated retinal or anterior segment tox...Continue Reading

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Citations

Aug 5, 2020·Bulletin of Experimental Biology and Medicine·S V SaakyanS S Tadevosyan
Jul 16, 2020·The British Journal of Ophthalmology·Jennifer NadelmannDavid H Abramson
Aug 8, 2020·International Journal of Retina and Vitreous·Silvia L FialhoRodrigo Jorge
Sep 24, 2020·European Journal of Ophthalmology·Ibadulla MirzayevNurdan Taçyıldız
Jun 5, 2021·European Journal of Ophthalmology·İrem KoçSepideh Lotfisadigh
Jul 13, 2021·Pharmacology Research & Perspectives·Alireza KhodabandeNiloufar Valipour
Jul 30, 2021·Frontiers in Pharmacology·Yacoub A YousefIbrahim Al-Nawaiseh
Jan 16, 2021·Ocular Oncology and Pathology·Jesse L BerryJonathan W Kim
Nov 11, 2021·Investigative Ophthalmology & Visual Science·Jessica V KaczmarekAnthony B Daniels

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Software Mentioned

Statistical Package for the Social Sciences ( SPSS )

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