PMID: 6397176Nov 1, 1984Paper

Ocular toxicology update

Australian Journal of Ophthalmology
Frederick T Fraunfelder, S M Meyer

Abstract

The National Registry of Drug-induced Ocular Side Effects has accumulated 13 cases of possible major haemopoietic responses from topical ocular chloramphenicol. Over 75 cases of major haemopoietic events from carbonic anhydrase inhibitors are also reviewed. While numerous reports of local ocular effects secondary to timolol have been received by the Registry, the more significant adverse effects are the same systemic side effects seen with any beta-receptor blocking agent. Data in the Registry have shown that allopurinol may be possibly associated with cataract formation. Severe cardiovascular effects with elevated blood pressure and stroke are uncommon systemic adverse reactions following topical ophthalmic 10% phenylephrine, but these systemic effects have also been seen secondary to concentrations of 2.5%. Other drugs, such as adrenaline (epinephrine), ecothiopate (echothiophate), practolol, thiabendazole, and penicillamine are suspected of causing ocular pseudopemphigoid.

References

Dec 1, 1975·Annals of Internal Medicine·Y Herishanu, P Rosenberg
May 1, 1977·Klinische Wochenschrift·H Lydtin
Oct 1, 1979·American Journal of Ophthalmology·C D McMahonJ Hetherington
Apr 1, 1978·American Journal of Ophthalmology·F T Fraunfelder, A F Scafidi
Oct 1, 1978·American Journal of Ophthalmology·C J AndersonR J Sturm
Aug 1, 1976·American Journal of Ophthalmology·J T PattenM R Allansmith
Aug 1, 1977·Archives of Ophthalmology·D L Epstein, W M Grant
Feb 1, 1972·Anesthesiology·D Solosko, R B Smith
Mar 1, 1982·American Journal of Ophthalmology·F T FraunfelderD J Kelly
Mar 1, 1982·American Journal of Ophthalmology·M Wellwood, G V Goresky
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May 1, 1980·Ophthalmology·E M Van Buskirk
Jan 11, 1965·JAMA : the Journal of the American Medical Association·R L ROSENTHAL, A BLACKMAN

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Citations

May 21, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sohail EjazChae Woong Lim
Jun 21, 2005·La Presse médicale·Marc LabetoulleClaire Le Jeunne
Mar 1, 1990·The Journal of Emergency Medicine·R K Cydulka, S Betzelos
Apr 28, 2009·Biomedical Microdevices·Ronalee LoEllis Meng

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