Ocular vestibular evoked myogenic potentials as a test for myasthenia gravis

Neurology
Yulia ValkoKonrad P Weber

Abstract

To explore whether ocular vestibular evoked myogenic potentials (oVEMP) can be used to detect a decrement in the extraocular muscle activity of patients with myasthenia gravis (MG). Twenty-seven patients with MG, including 13 with isolated ocular and 14 with generalized MG, and 28 healthy controls participated. We applied repetitive vibration stimuli to the forehead and recorded the activity of the inferior oblique muscle with 2 surface electrodes placed beneath the eyes. To identify the oVEMP parameters with the highest sensitivity and specificity, we evaluated the decrement over 10 stimulus repetitions at 3 different repetition rates (3 Hz, 10 Hz, and 20 Hz). Repetitive stimulation at 20 Hz yielded the best differentiation between patients with MG and controls with a sensitivity of 89% and a specificity of 64% when using a unilateral decrement of ≥15.2% as cutoff. When using a bilateral decrement of ≥20.4% instead, oVEMP allowed differentiation of MG from healthy controls with 100% specificity, but slightly reduced sensitivity of 63%. For both cutoffs, sensitivity was similar in isolated ocular and generalized MG. Our study demonstrates that the presence of an oVEMP decrement is a sensitive and specific marker for MG. This te...Continue Reading

Associated Clinical Trials

Feb 10, 2017·Konrad Peter Weber

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Citations

Jan 23, 2016·Neurology·Sashank Prasad, G Michael Halmagyi
Feb 27, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Agustina M LascanoMargitta Seeck
Nov 15, 2017·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Julia Dlugaiczyk
Oct 5, 2017·Praxis·Yulia Valko, Konrad P Weber
May 3, 2019·Nature Reviews. Disease Primers·Nils Erik GilhusJan J G M Verschuuren
Mar 7, 2020·Journal of Neurology·Yury V GavrilovYulia Valko
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Dec 18, 2020·Frontiers in Neurology·Amelia Evoli, Raffaele Iorio
Jun 17, 2021·Muscle & Nerve·Goknur Selen KocakMeryem Merve Oren

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