PMID: 8592327Nov 1, 1995Paper

Oculocutaneous albinism among schoolchildren in Harare, Zimbabwe

Journal of Medical Genetics
F Kagore, P M Lund

Abstract

The term oculocutaneous albinism (OCA) covers a range of autosomal recessive genetic conditions involving hypopigmentation of the skin, hair, and eyes. In southern African black ethnic groups the tyrosinase positive form, OCA2, is predominant, with few cases of tyrosinase negative OCA1. The prevalence of OCA2 in schoolchildren in Harare, the capital city of Zimbabwe, was found to be 1 in 2833. The gene frequency for OCA2 was 0.0188, with a carrier frequency of 1 in 27. Most of the pupils with albinism belong to the majority Shona ethnic group. As consanguineous marriages are discouraged in the Shona culture this high rate is likely to be a result of genetic drift in a relatively small population showing limited mobility. OCA pupils were found in more than a third of the secondary schools in Harare, emphasising the importance of distributing information on albinism and its management widely throughout the school system.

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Citations

Aug 1, 1996·Molecular Medicine Today·W S OettingR A King
Jul 14, 1999·Thrombosis Research·A McNicol, S J Israels
Feb 23, 2002·Journal of Dermatological Science·Eriko NakamuraYasushi Tomita
Jul 10, 2003·Journal of Dermatological Science·Tamio SuzukiYasushi Tomita
Aug 1, 1996·Journal of Medical Genetics·P M Lund
Oct 10, 1997·Journal of Medical Genetics·P M LundM H Brilliant
Aug 19, 2006·BMC Public Health·Esther S HongMichael H Repacholi
Nov 6, 2007·Orphanet Journal of Rare Diseases·Karen GrønskovKaren Brondum-Nielsen
Nov 26, 2010·Dermatologic Clinics·Andres E Cruz-InigoAisha Sethi
Jul 3, 2007·International Journal of Nursing Studies·Julie S Taylor, Patricia Lund
Oct 10, 2014·Photochemistry and Photobiology·Caradee Y WrightRichard W Hertle

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