Oculomotor nerve regeneration after aneurysm surgery

American Journal of Ophthalmology
J M KernsM G Alper

Abstract

A 57-year-old woman had symptoms of oculomotor nerve palsy first appearing one year before successful surgical ligation of a saccular aneurysm arising from the right posterior cerebral artery. During the subsequent postoperative period of two years, oculomotor nerve functions improved as the result of regeneration. Extensive morphometric evaluation of the regenerated nerve was compared to the normal side at the light microscopic level. The affected nerve showed a reduction in the transverse area (62%), estimated number of fibers (49%), and mean diameter of myelinated axons (23%). The normal g-ratio of axon to total diameter was almost constant at 0.64, but on the regenerated side it increased to 0.73. An increase in unmyelinated axons and connective tissue endoneurium was evident at the ultrastructural level. The significance of these marked quantitative changes was compared to the partial return of oculomotor nerve function.

References

Jan 1, 1977·American Journal of Ophthalmology·N R Miller
Jun 11, 1975·Journal of Neurosurgery·I Kasoff, D L Kelly
Apr 14, 1970·Brain Research·R L Friede, A J Martinez
Feb 1, 1972·The Journal of Comparative Neurology·R L Friede
Mar 1, 1957·Journal of Neurosurgery·P HARRIS, G B UDVARHELYI
Oct 1, 1957·The British Journal of Ophthalmology·F B WALSH
May 1, 1964·The Journal of Physiology·B G CRAGG, P K THOMAS
Oct 1, 1964·Journal of Neurology, Neurosurgery, and Psychiatry·F W KERR, O W HOLLOWELL
Sep 1, 1951·The Journal of Physiology·W A H RUSHTON
Mar 25, 1943·The Journal of Physiology·E Gutmann, F K Sanders
Dec 1, 1946·Brain : a Journal of Neurology·S SUNDERLAND, E S R HUGHES
Oct 1, 1939·Journal of Neurology and Psychiatry·M B Bender, J F Fulton

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Citations

Feb 25, 2005·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Edward G BuckleyTimothy Saunders
Mar 31, 2005·Journal of Neurosurgery·Hisham Al-KhayatDuke Samson
Aug 24, 1999·The European Journal of Neuroscience·M E CorthésyE Welker
Jan 15, 1980·The Journal of Comparative Neurology·J M Kerns
Dec 1, 1981·Journal of Neurology, Neurosurgery, and Psychiatry·M P BarnesI R Williams
Aug 1, 1984·The British Journal of Ophthalmology·J S Elston
Jan 1, 1991·Acta neurochirurgica·S GiombiniF Pluchino
Feb 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M Martorina, E Porté
Nov 7, 2012·Ophthalmic Plastic and Reconstructive Surgery·Kyung-Ah Park, Sei Yeul Oh

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