Oculomotor nerve regeneration in rats. Functional, histological, and neuroanatomical studies

Journal of Neurosurgery
E FernandezA Sbriccoli

Abstract

To study oculomotor nerve regeneration in rats, the oculomotor nerve was approached microsurgically and was sectioned at the base of the skull. The nerve stumps were reapproximated and affixed with a plasma clot in Group I animals and were separated by a gap in Group II animals. Visceral eye motility was evaluated weekly between 1 day and 40 weeks after surgery by recording the pupillary diameter under standardized photic stimulation. Somatic eye motility was assessed after 26 weeks by measuring the ocular displacement evoked by vestibular stimulation in the horizontal and vertical planes. Nerve regeneration was documented histologically and morphometrically at 8, 16, and 40 weeks after section. The selectivity of axonal regeneration to the extraocular muscles was investigated after 26 weeks by mapping (with injection of retrograde horseradish peroxidase) the motoneurons that supplied each reinnervated muscle. Between 6 and 20 weeks after section, the pupil diameter showed a progressive reduction in Group I rats, and no changes were observed in Group II rats. Compared with normal rats, the amplitude of horizontal and vertical ocular displacements was decreased, respectively, by 30% and 45% in Group I and by 65% and 80% in Group...Continue Reading

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Citations

Dec 14, 1999·Microsurgery·T MenovskyJ J van Overbeeke
Feb 9, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Min YangShiting Li
Oct 19, 2011·Neurosurgical Review·Ulf WesterlundTiit Mathiesen
Jul 9, 2013·Journal of Molecular Neuroscience : MN·Ningxi ZhuShiting Li
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Jan 3, 2012·Journal of Neurosurgery. Pediatrics·Scott J TurnerRobert Ouvrier
Aug 15, 1996·Neurosurgical Focus·T Menovsky, J J van Overbeeke
Feb 6, 1998·Journal of Neurosurgery·J J van OverbeekeT Menovsky
Jul 16, 2014·Journal of Molecular Neuroscience : MN·Ningxi ZhuShiting Li
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Apr 18, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Verónica CompanyEduardo Puelles
Apr 1, 1992·Neurosurgery·R Krajewski
Jan 25, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ignacio Hernández-MoratoArán Pascual-Font
Dec 3, 2016·Neural Regeneration Research·Lei DuShi-Ting Li
Mar 1, 2013·Journal of Anatomy·Ignacio Hernández-MoratoArán Pascual-Font

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Methods Mentioned

BETA
light microscopy

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