PMID: 9533602Apr 9, 1998Paper

Oculosympathetic alterations in migraine patients

Cephalalgia : an International Journal of Headache
M De MarinisF Carletto

Abstract

Oculosympathetic function was studied in 20 headache-free migraine patients and in 20 controls. Pupillary investigation was performed under basal conditions, and after instillation of tyramine (2%) and phenylephrine (1%) eyedrops. Each test was performed twice shortly after a spontaneous attack and then repeated after 7 and 15 days. In the patients, the normal mydriatic response induced by tyramine was significantly (p<0.001) reduced and phenylephrine instillation caused a significant (p<0.01) pupillary dilatation in both the assessments performed shortly after the attack. These abnormal responses were bilateral in all patients and slightly anisocoric in some. They were significantly (p<0.001) more pronounced in the patients who had pain and pronounced vascular features. The reduced oculosympathetic response to tyramine, as well as the hypersensitivity to phenylephrine, was less evident 7 days after the attack and absent after 15 days. A transient and bilateral post-ganglionic oculosympathetic hypofunction, with adrenoceptor hypersensitivity, was found to be temporally related to the migraine attack, regardless of the side or predominant side of pain.

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Citations

Aug 19, 2004·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Deacon E Harle, Bruce J W Evans
Dec 21, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Marco SimonettoGiovanni Masè
Feb 8, 2000·Current Opinion in Ophthalmology·A Kawasaki
Apr 28, 2005·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Deacon E HarleBruce J W Evans
Oct 23, 2002·Headache·Daniel E Jacome
Nov 29, 2020·European Journal of Ophthalmology·Merve Beyza YildizYılmaz Çetinkaya

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