Odanacatib: an emerging novel treatment alternative for postmenopausal osteoporosis

Women's Health
Thomas C SchultzElena M Umland

Abstract

Odanacatib represents a novel treatment option in the approach of postmenopausal women. Postmenopausal women with osteoporosis experience a disturbance in bone remodeling wherein bone resorption exceeds bone formation. Cathepsin K is a lysosomal cysteine protease found primarily in osteoclasts that plays a major role in the breakdown of bone via its collagenase properties. Targeting a new area of pathophysiology, odanacatib inhibits cathepsin K to reduce bone resorption while preserving bone formation. Phase II and III trials have shown efficacy in increasing bone mineral density in the target treatment group. Overall, safety studies have found odanacatib to be well-tolerated and comparable to placebo; however, some imbalances in adverse events have been observed in the Phase III trials. Current and future studies will analyze the long-term ability of odanacatib in preventing bone fracture.

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Citations

Jul 9, 2016·Vascular Pharmacology·Cristina Vassalle, Annamaria Mazzone

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Methods Mentioned

BETA
x-ray
biopsy

Clinical Trials Mentioned

NCT00863590
NCT00770159
NCT01068262
NCT00112437
NCT00885170

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