Odd-paired controls frequency doubling in Drosophila segmentation by altering the pair-rule gene regulatory network

ELife
Erik Clark, Michael Akam

Abstract

The Drosophila embryo transiently exhibits a double-segment periodicity, defined by the expression of seven 'pair-rule' genes, each in a pattern of seven stripes. At gastrulation, interactions between the pair-rule genes lead to frequency doubling and the patterning of 14 parasegment boundaries. In contrast to earlier stages of Drosophila anteroposterior patterning, this transition is not well understood. By carefully analysing the spatiotemporal dynamics of pair-rule gene expression, we demonstrate that frequency-doubling is precipitated by multiple coordinated changes to the network of regulatory interactions between the pair-rule genes. We identify the broadly expressed but temporally patterned transcription factor, Odd-paired (Opa/Zic), as the cause of these changes, and show that the patterning of the even-numbered parasegment boundaries relies on Opa-dependent regulatory interactions. Our findings indicate that the pair-rule gene regulatory network has a temporally modulated topology, permitting the pair-rule genes to play stage-specific patterning roles.

References

Oct 5, 2017·Proceedings of the National Academy of Sciences of the United States of America·Xin ZhuEzzat El-Sherif
Dec 19, 2019·Open Biology·Eléanor SimonIsabel Guerrero
Oct 18, 2019·G3 : Genes - Genomes - Genetics·Ben J VincentMark Rebeiz
Aug 10, 2017·Development Genes and Evolution·Chong Pyo ChoeSusan J Brown
Oct 19, 2017·History and Philosophy of the Life Sciences·Ellen V Rothenberg
Oct 2, 2018·ELife·Felix Kaufholz, Natascha Turetzek
May 8, 2019·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Ellen V Rothenberg
Nov 25, 2020·Current Opinion in Hematology·Ellen V Rothenberg, Berthold Göttgens

Citations

Sep 1, 1992·Genes & Development·A S Manoukian, H M Krause
Sep 1, 1991·Genes & Development·D MorrisseyM P Weir
Sep 1, 1990·Trends in Genetics : TIG·M J Pankratz, H Jäckle
Sep 1, 1988·Genes & Development·M P WeirG Schubiger
Mar 1, 1989·Genes & Development·C R DearolfC S Parker
Dec 1, 1988·Genes & Development·M FraschM Levine
Aug 1, 1988·Genes & Development·K HowardC Rushlow
Feb 21, 1985·Nature·A Martinez-Arias, P A Lawrence
Oct 30, 1980·Nature·C Nüsslein-Volhard, E Wieschaus
Aug 1, 1994·Current Opinion in Genetics & Development·S DiNardoP H O'Farrell
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·K M CadiganW J Gehring
Sep 1, 1993·Mechanisms of Development·M Klingler, J P Gergen

Related Concepts

Embryo
Biologic Segmentation
Entire Embryo
odd
Drosophila
Gene Expression
Genes, Regulator
ZIC1
Drug Interactions
Gene Regulatory Networks

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.