PMID: 7536506Nov 1, 1994Paper

Odontogenic myxoma--characterisation of the extracellular matrix (ECM) of the tumour stroma

European Journal of Cancer. Part B, Oral Oncology
A Schmidt-WesthausenP A Reichart

Abstract

In order to elucidate the origin of the odontogenic myxoma, the composition and the structural organisation of the extracellular matrix (ECM) of this tumour were characterised. Collagen type I, VI, procollagen type III, undulin, tenascin and fibronectin were demonstrated in biopsy material of 4 cases by polyclonal antibodies. The tumour stroma showed a pronounced reaction for collagen type I. Fibroblasts displayed an intense intracytoplasmatic reaction for procollagen type III, and collagen type I was not found in the fibroblasts of the adjacent normal oral mucosa. In contrast to the surrounding connective tissue, label for collagen type VI was weak, as was the reaction for fibronectin and tenascin. Undulin was almost undetectable. The immunohistochemical results suggest that the odontogenic myxoma is characterised by an as yet unobserved structural organisation of ECM proteins, a secretion defect of fibrillar collagens type I and III with no resemblance to physiological tooth development.

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Citations

Dec 10, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Brian T BastJoseph A Regezi
Jun 1, 2013·International Journal of Oral Science·Jaume Miranda RiusLluís Brunet
Aug 15, 2012·Proteome Science·Alejandro García-MuñozGuillermo Mendoza-Hernández
Jul 1, 2008·Journal of Oral Science·Sueli P H MiyagiMárcia M Marques
Nov 5, 1997·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·T KawaiH Fuchihata
Jun 2, 2015·Journal of Maxillofacial and Oral Surgery·George RallisPanagiotis Stathopoulos
Aug 7, 2014·The Journal of Contemporary Dental Practice·Shahroo Etemad-MoghadamMojgan Alaeddini
Nov 13, 2007·Oral Oncology·Guillermo Martínez-MataHugo Domínguez-Malagón

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