Odor discrimination in patients with frontal lobe damage and Korsakoff's syndrome

Neuropsychologia
Hilleke E Hulshoff PolJan M van Ree

Abstract

The involvement of the frontal cortex and thalamic nucleus in odor discrimination in humans was assessed. Six patients with frontal lobe brain damage, seven patients with alcoholic Korsakoff's syndrome and 16 healthy comparison subjects completed odor detection and odor discrimination tasks. Multivariate general linear modeling with age as a covariant revealed significantly decreased odor discrimination ability in frontal lobe damaged patients and marginally decreased odor discrimination ability in Korsakoff's syndrome patients as compared to the healthy comparison subjects. No deficits were found in odor detection ability. The findings suggest that in human odor discrimination, there is more involvement of cortico-cortical pathways than of thalamo-cortical pathways.

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Citations

Sep 8, 2010·Neurocase·Wendy W P ThamLaurie A Miller
May 15, 2013·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Marta Zaffira ContiLuca Rozzini
Sep 26, 2006·Developmental Neuropsychology·Eva PirogovskyClaire Murphy
Oct 6, 2009·Brain Research Reviews·Wendy W P ThamLaurie A Miller
Mar 27, 2003·Alcoholism, Clinical and Experimental Research·Claudia I RuppW Wolfgang Fleischhacker
Aug 11, 2006·Alcoholism, Clinical and Experimental Research·Claudia I RuppMartin Kurz
Nov 3, 2007·Neuropsychologia·Esther FujiwaraBrian Levine
Oct 7, 2015·Frontiers in Neural Circuits·Emmanuelle Courtiol, Donald A Wilson
Aug 24, 2010·Neuropsychologia·David H Zald, Charissa Andreotti
Aug 10, 2013·Journal of the Neurological Sciences·Jennifer J StampsKenneth M Heilman

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