PMID: 9438794Jan 23, 1998Paper

Odor-guided fear conditioning in rats: 1. Acquisition, retention, and latent inhibition

Behavioral Neuroscience
T OttoK Rajewski

Abstract

Three experiments examined the acquisition, retention, and latent inhibition of odor-guided fear conditioning in rats. The results of Experiment 1 indicate that forward conditioned stimulus (CS)-unconditioned stimulus (US) pairings resulted in robust freezing responses to subsequent presentation of the CS alone. In Experiment 2, rats in one group (PRE) received unreinforced preexposures to the odorant CS, and those in a second group (NON) were not preexposed to the odorant. All rats then received forward CS-US pairings. PRE rats exhibited a marked attenuation of freezing to subsequent exposure to the CS relative to NON rats. All rats were then retested at one of the following posttraining delays: 17, 24, or 31 days. Freezing behavior of the NON rats declined significantly across these delays, whereas rats in the PRE group froze no more at any delay than they had 24 hr after training. Experiment 3 examined the contextual specificity of latent inhibition. Only those rats that were preexposed and trained in the same context exhibited latent inhibition. These results indicate that odor-guided fear conditioning is a robust and useful paradigm suitable for future studies of the neural bases of associative learning.

Citations

Aug 21, 2013·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Susanne SchwarzeVera Schluessel
Feb 11, 2003·Physiology & Behavior·Rick Richardson, Gavan P McNally
May 10, 2000·Behavioural Brain Research·T OttoC Herzog
Mar 16, 2002·Behavioral Neuroscience·Gayla Y Paschall, Michael Davis
Apr 29, 2004·Behavioral Neuroscience·Stephanie Moriceau, Regina M Sullivan
Jan 20, 2006·Behavioral Neuroscience·Andrew TalkMichael Gabriel
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May 20, 2008·Neurobiology of Learning and Memory·Teresa Camille Parsons, Tim Otto
Apr 9, 2014·Frontiers in Endocrinology·Millie Rincón-Cortés, Regina M Sullivan
May 4, 2007·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·Regina M Sullivan

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