Odorant ligands for the CO2 receptor in two Anopheles vectors of malaria

Scientific Reports
Iliano V Coutinho-AbreuAnandasankar Ray

Abstract

Exhaled CO2 is an important host-seeking cue for Anopheles mosquitoes, which is detected by a highly conserved heteromeric receptor consisting of three 7-transmembrane proteins Gr22, Gr23, and Gr24. The CO2 receptor neuron has been shown to also respond sensitively to a variety of odorants in Aedes aegypti. The detection of CO2 is important for upwind navigation and for enhancing the attraction to body heat as well as to skin odorants. The orthologs of the CO2 receptor proteins are present in malaria-transmitting mosquitoes like Anopheles coluzzii and Anopheles sinensis. Activators and inhibitors of the CO2-neuron were tested on the maxillary palps in these two species by single-sensillum electrophysiology. The electrophysiological testing of three prolonged-activator odorants identified originally in Aedes aegypti also showed varying ability to reduce the CO2-ellicited increase in spikes. These findings provide a foundation for comparing the functional conservation with the evolutionary conservation of an important class of odorant receptor. The identification of a suite of natural odorants that can be used to modify the CO2-detection pathway may also contribute to odor-blends that can alter the behavior of these disease trans...Continue Reading

References

Jul 27, 2005·The Journal of Experimental Biology·Teun DekkerRing T Cardé
Sep 4, 2007·Current Biology : CB·Tan LuLaurence J Zwiebel
Mar 28, 2008·Molecular Biology and Evolution·Si Quang Le, Olivier Gascuel
Jul 21, 2009·Journal of Insect Science·Hugh M Robertson, Lauren B Kent
Aug 28, 2009·Nature·Stephanie Lynn Turner, Anandasankar Ray
Feb 5, 2010·Nature·Allison F CareyJohn R Carlson
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Guirong WangLaurence J Zwiebel
Jun 4, 2011·Nature·Stephanie Lynn TurnerAnandasankar Ray
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Oct 19, 2013·ELife·Sean Michael BoyleAnandasankar Ray
Dec 10, 2013·Cell·Genevieve M TauxeAnandasankar Ray
Aug 15, 2014·Journal of Biosciences·Anandasankar RayJohn R Carlson
Jul 21, 2015·Current Biology : CB·Floris van BreugelMichael H Dickinson
Jul 24, 2015·Current Opinion in Neurobiology·Anandasankar Ray
Jul 1, 1985·Evolution; International Journal of Organic Evolution·Joseph Felsenstein

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Citations

Feb 27, 2021·Interface Focus·Stephanie Turner ChenAnandasankar Ray
Apr 23, 2021·Chemical Senses·Joanna K KonopkaChristopher J Potter
Aug 21, 2021·Frontiers in Physiology·Qiuyan ChenGuirong Wang

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